1kzn

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{{Seed}}
 
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[[Image:1kzn.png|left|200px]]
 
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==Crystal Structure of E. coli 24kDa Domain in Complex with Clorobiocin==
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The line below this paragraph, containing "STRUCTURE_1kzn", creates the "Structure Box" on the page.
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<StructureSection load='1kzn' size='340' side='right'caption='[[1kzn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KZN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBN:CLOROBIOCIN'>CBN</scene></td></tr>
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{{STRUCTURE_1kzn| PDB=1kzn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzn OCA], [https://pdbe.org/1kzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kzn RCSB], [https://www.ebi.ac.uk/pdbsum/1kzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kzn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GYRB_ECOLI GYRB_ECOLI] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051843</ref> <ref>PMID:18642932</ref> <ref>PMID:20675723</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/1kzn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kzn ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of E. coli 24kDa Domain in Complex with Clorobiocin===
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==See Also==
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12044152}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12044152 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12044152}}
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==About this Structure==
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1KZN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZN OCA].
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==Reference==
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DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose., Lafitte D, Lamour V, Tsvetkov PO, Makarov AA, Klich M, Deprez P, Moras D, Briand C, Gilli R, Biochemistry. 2002 Jun 11;41(23):7217-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12044152 12044152]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Briand, C.]]
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[[Category: Briand C]]
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[[Category: Deprez, P.]]
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[[Category: Deprez P]]
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[[Category: Gilli, R.]]
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[[Category: Gilli R]]
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[[Category: Klich, M.]]
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[[Category: Klich M]]
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[[Category: Lafitte, D.]]
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[[Category: Lafitte D]]
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[[Category: Lamour, V.]]
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[[Category: Lamour V]]
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[[Category: Makarov, A A.]]
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[[Category: Makarov AA]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Tsvetkov, P O.]]
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[[Category: Tsvetkov PO]]
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[[Category: Clorobiocin]]
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[[Category: Gyrase b]]
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[[Category: Topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:22:24 2008''
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Current revision

Crystal Structure of E. coli 24kDa Domain in Complex with Clorobiocin

PDB ID 1kzn

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