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1l1m

From Proteopedia

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{{Seed}}
 
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[[Image:1l1m.png|left|200px]]
 
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==SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1==
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The line below this paragraph, containing "STRUCTURE_1l1m", creates the "Structure Box" on the page.
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<StructureSection load='1l1m' size='340' side='right'caption='[[1l1m]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l1m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1m OCA], [https://pdbe.org/1l1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1m RCSB], [https://www.ebi.ac.uk/pdbsum/1l1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1m ProSAT]</span></td></tr>
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{{STRUCTURE_1l1m| PDB=1l1m | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI] Repressor of the lactose operon. Binds allolactose as an inducer.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1m ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1===
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==See Also==
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*[[Lac repressor|Lac repressor]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12065400}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12065400 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12065400}}
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==About this Structure==
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1L1M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1M OCA].
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==Reference==
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Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain., Kalodimos CG, Bonvin AM, Salinas RK, Wechselberger R, Boelens R, Kaptein R, EMBO J. 2002 Jun 17;21(12):2866-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12065400 12065400]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Boelens, R.]]
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[[Category: Boelens R]]
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[[Category: Bonvin, A M.J J.]]
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[[Category: Bonvin AMJJ]]
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[[Category: Kalodimos, C G.]]
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[[Category: Kalodimos CG]]
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[[Category: Kaptein, R.]]
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[[Category: Kaptein R]]
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[[Category: Salinas, R K.]]
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[[Category: Salinas RK]]
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[[Category: Wechselberger, R.]]
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[[Category: Wechselberger R]]
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[[Category: Asymmetric dna-binding]]
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[[Category: Hth]]
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[[Category: Lac operon]]
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[[Category: Lac repressor]]
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[[Category: Natural lac operator]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:29:54 2008''
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Current revision

SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1

PDB ID 1l1m

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