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1l1o

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{{Seed}}
 
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[[Image:1l1o.png|left|200px]]
 
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==Structure of the human Replication Protein A (RPA) trimerization core==
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The line below this paragraph, containing "STRUCTURE_1l1o", creates the "Structure Box" on the page.
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<StructureSection load='1l1o' size='340' side='right'caption='[[1l1o]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l1o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1O FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1l1o| PDB=1l1o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1o OCA], [https://pdbe.org/1l1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1o RCSB], [https://www.ebi.ac.uk/pdbsum/1l1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RFA3_HUMAN RFA3_HUMAN] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/1l1o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l1o ConSurf].
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<div style="clear:both"></div>
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===Structure of the human Replication Protein A (RPA) trimerization core===
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==See Also==
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*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11927569}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11927569 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11927569}}
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==About this Structure==
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1L1O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1O OCA].
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==Reference==
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Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA., Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A, EMBO J. 2002 Apr 2;21(7):1855-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11927569 11927569]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkareva, E V.]]
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[[Category: Bochkareva EV]]
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[[Category: Korolev, S.]]
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[[Category: Korolev S]]
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[[Category: Lees-Miller, S P.]]
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[[Category: Lees-Miller SP]]
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[[Category: Eukaryotic ssb]]
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[[Category: Ob-fold]]
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[[Category: Ssdna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:30:16 2008''
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Current revision

Structure of the human Replication Protein A (RPA) trimerization core

PDB ID 1l1o

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