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1l1w

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{{Seed}}
 
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[[Image:1l1w.png|left|200px]]
 
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==NMR structure of a SRP19 binding domain in human SRP RNA==
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The line below this paragraph, containing "STRUCTURE_1l1w", creates the "Structure Box" on the page.
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<StructureSection load='1l1w' size='340' side='right'caption='[[1l1w]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1W FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1w OCA], [https://pdbe.org/1l1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1w RCSB], [https://www.ebi.ac.uk/pdbsum/1l1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1w ProSAT]</span></td></tr>
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{{STRUCTURE_1l1w| PDB=1l1w | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Assembly of the human signal recognition particle (SRP) requires SRP19 protein to bind to helices 6 and 8 of SRP RNA. In the present study, structure of a 29-mer RNA composing the SRP19 binding site in helix 6 was determined by NMR spectroscopy. The two A:C mismatches were continuously stacked to each other and formed wobble type A:C base pairs. The GGAG tetraloop in helix 6 was found to adopt a similar conformation to that of GNRA tetraloop, suggesting that these tetraloops are included in an extensive new motif GNRR. Compared with the crystal structure of helix 6 in complex with SRP19 determined previously, the GGAG tetraloop in the complex was found to adopt a similar conformation to the free form, although the loop structure becomes more open upon SRP19 binding. Thus, SRP19 is thought to recognize the overall fold of the GGAG loop.
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===NMR structure of a SRP19 binding domain in human SRP RNA===
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Solution structure of a SRP19 binding domain in human SRP RNA.,Sakamoto T, Morita S, Tabata K, Nakamura K, Kawai G J Biochem. 2002 Aug;132(2):177-82. PMID:12153712<ref>PMID:12153712</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12153712}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1l1w" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12153712 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12153712}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1W OCA].
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[[Category: Large Structures]]
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[[Category: Kawai G]]
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==Reference==
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[[Category: Morita S]]
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Solution structure of a SRP19 binding domain in human SRP RNA., Sakamoto T, Morita S, Tabata K, Nakamura K, Kawai G, J Biochem. 2002 Aug;132(2):177-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12153712 12153712]
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[[Category: Nakamura K]]
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[[Category: Kawai, G.]]
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[[Category: Sakamoto T]]
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[[Category: Morita, S.]]
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[[Category: Tabata K]]
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[[Category: Nakamura, K.]]
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[[Category: Sakamoto, T.]]
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[[Category: Tabata, K.]]
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[[Category: Gnrr]]
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[[Category: Mismatch]]
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[[Category: Rna hairpin]]
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[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:31:09 2008''
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Current revision

NMR structure of a SRP19 binding domain in human SRP RNA

PDB ID 1l1w

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