This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1i17

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1i17" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i17" /> '''NMR STRUCTURE OF MOUSE DOPPEL 51-157'''<br /...)
Current revision (07:43, 3 April 2024) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1i17.gif|left|200px]]<br /><applet load="1i17" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1i17" />
 
-
'''NMR STRUCTURE OF MOUSE DOPPEL 51-157'''<br />
 
-
==Overview==
+
==NMR STRUCTURE OF MOUSE DOPPEL 51-157==
-
The downstream prion-like protein (doppel, or Dpl) is a paralog of the, cellular prion protein, PrP(C). The two proteins have approximately 25%, sequence identity, but seem to have distinct physiologic roles. Unlike, PrP(C), Dpl does not support prion replication; instead, overexpression of, Dpl in the brain seems to cause a completely different neurodegenerative, disease. We report the solution structure of a fragment of recombinant, mouse Dpl (residues 26-157) containing a globular domain with three, helices and a small amount of beta-structure. Overall, the topology of Dpl, is very similar to that of PrP(C). Significant differences include a, marked kink in one of the helices in Dpl, and a different orientation of, the two short beta-strands. Although the two proteins most likely arose, through duplication of a single ancestral gene, the relationship is now so, distant that only the structures retain similarity; the functions have, diversified along with the sequence.
+
<StructureSection load='1i17' size='340' side='right'caption='[[1i17]]' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1i17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I17 FirstGlance]. <br>
-
1I17 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I17 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i17 OCA], [https://pdbe.org/1i17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i17 RCSB], [https://www.ebi.ac.uk/pdbsum/1i17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i17 ProSAT]</span></td></tr>
-
==Reference==
+
</table>
-
Two different neurodegenerative diseases caused by proteins with similar structures., Mo H, Moore RC, Cohen FE, Westaway D, Prusiner SB, Wright PE, Dyson HJ, Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2352-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11226243 11226243]
+
== Function ==
 +
[https://www.uniprot.org/uniprot/PRND_MOUSE PRND_MOUSE]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/1i17_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i17 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Single protein]]
+
[[Category: Cohen FE]]
-
[[Category: Cohen, F.E.]]
+
[[Category: Dyson HJ]]
-
[[Category: Dyson, H.J.]]
+
[[Category: Mo H]]
-
[[Category: Mo, H.]]
+
[[Category: Moore RC]]
-
[[Category: Moore, R.C.]]
+
[[Category: Prusiner SB]]
-
[[Category: Prusiner, S.B.]]
+
[[Category: Westaway D]]
-
[[Category: Westaway, D.]]
+
[[Category: Wright PE]]
-
[[Category: Wright, P.E.]]
+
-
[[Category: doppel]]
+
-
[[Category: dpl]]
+
-
[[Category: mouse doppel]]
+
-
[[Category: prion]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:57:59 2007''
+

Current revision

NMR STRUCTURE OF MOUSE DOPPEL 51-157

PDB ID 1i17

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i17"
Personal tools