1i2l

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(New page: 200px<br /><applet load="1i2l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i2l, resolution 2.3&Aring;" /> '''DEOXYCHORISMATE LYASE...)
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[[Image:1i2l.jpg|left|200px]]<br /><applet load="1i2l" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1i2l, resolution 2.3&Aring;" />
 
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'''DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR'''<br />
 
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==About this Structure==
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==DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR==
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1I2L is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with DCS as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I2L OCA].
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<StructureSection load='1i2l' size='340' side='right'caption='[[1i2l]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1i2l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I2L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCS:D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE'>DCS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i2l OCA], [https://pdbe.org/1i2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i2l RCSB], [https://www.ebi.ac.uk/pdbsum/1i2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i2l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PABC_ECOLI PABC_ECOLI] Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.<ref>PMID:1644759</ref> <ref>PMID:2251281</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/1i2l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i2l ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Eisenstein, E.]]
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[[Category: Eisenstein E]]
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[[Category: Fisher, K.E.]]
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[[Category: Fisher KE]]
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[[Category: Howard, A.J.]]
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[[Category: Howard AJ]]
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[[Category: Jensen, P.Y.]]
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[[Category: Jensen PY]]
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[[Category: Ladner, J.E.]]
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[[Category: Ladner JE]]
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[[Category: Pachikara, A.S.]]
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[[Category: Pachikara AS]]
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[[Category: Parsons, J.F.]]
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[[Category: Parsons JF]]
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[[Category: Tordova, M.]]
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[[Category: Tordova M]]
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[[Category: DCS]]
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[[Category: aminodeoxychorismate]]
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[[Category: d-cycloserine]]
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[[Category: lyase]]
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[[Category: pabc]]
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[[Category: pyridoxal phosphate]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:00:10 2007''
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Current revision

DEOXYCHORISMATE LYASE FROM ESCHERICHIA COLI WITH INHIBITOR

PDB ID 1i2l

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