1l8o

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{{Seed}}
 
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[[Image:1l8o.png|left|200px]]
 
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==Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase==
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The line below this paragraph, containing "STRUCTURE_1l8o", creates the "Structure Box" on the page.
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<StructureSection load='1l8o' size='340' side='right'caption='[[1l8o]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8O FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene></td></tr>
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{{STRUCTURE_1l8o| PDB=1l8o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8o OCA], [https://pdbe.org/1l8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8o RCSB], [https://www.ebi.ac.uk/pdbsum/1l8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8o ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[https://omim.org/entry/614023 614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8o ConSurf].
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<div style="clear:both"></div>
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===Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase===
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==See Also==
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*[[Phosphoserine phosphatase|Phosphoserine phosphatase]]
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== References ==
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12213811 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12213811}}
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==About this Structure==
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1L8O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8O OCA].
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==Reference==
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Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase., Kim HY, Heo YS, Kim JH, Park MH, Moon J, Kim E, Kwon D, Yoon J, Shin D, Jeong EJ, Park SY, Lee TG, Jeon YH, Ro S, Cho JM, Hwang KY, J Biol Chem. 2002 Nov 29;277(48):46651-8. Epub 2002 Sep 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12213811 12213811]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoserine phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Heo YS]]
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[[Category: Heo, Y S.]]
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[[Category: Hwang KY]]
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[[Category: Hwang, K Y.]]
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[[Category: Jeon YH]]
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[[Category: Jeon, Y H.]]
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[[Category: Kim HY]]
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[[Category: Kim, H Y.]]
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[[Category: Kim JH]]
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[[Category: Kim, J H.]]
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[[Category: Lee TG]]
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[[Category: Lee, T G.]]
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[[Category: Moon J]]
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[[Category: Moon, J.]]
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[[Category: Park MH]]
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[[Category: Park, M H.]]
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[[Category: Park SY]]
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[[Category: Park, S Y.]]
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[[Category: Ro S]]
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[[Category: Ro, S.]]
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[[Category: Conformational rearrangement]]
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[[Category: Phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:57:23 2008''
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Current revision

Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase

PDB ID 1l8o

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