1i30

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(New page: 200px<br /><applet load="1i30" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i30, resolution 2.4&Aring;" /> '''E. COLI ENOYL REDUCTA...)
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[[Image:1i30.gif|left|200px]]<br /><applet load="1i30" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1i30, resolution 2.4&Aring;" />
 
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'''E. COLI ENOYL REDUCTASE +NAD+SB385826'''<br />
 
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==Overview==
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==E. Coli Enoyl Reductase +NAD+SB385826==
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1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and, Escherichia coli enoyl acyl carrier protein reductase (FabI) have been, identified. Crystal structure data shows the inhibitor 1 bound in the, enzyme active site of E. coli FabI.
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<StructureSection load='1i30' size='340' side='right'caption='[[1i30]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1i30]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I30 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=826:1,3,4,9-TETRAHYDRO-2-(HYDROXYBENZOYL)-9-[(4-HYDROXYPHENYL)METHYL]-6-METHOXY-2H-PYRIDO[3,4-B]INDOLE'>826</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i30 OCA], [https://pdbe.org/1i30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i30 RCSB], [https://www.ebi.ac.uk/pdbsum/1i30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i30 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i3/1i30_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i30 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1I30 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NAD and 826 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1I30 OCA].
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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== References ==
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==Reference==
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<references/>
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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11514139 11514139]
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__TOC__
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[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Janson, C.A.]]
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[[Category: Janson CA]]
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[[Category: Miller, W.H.]]
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[[Category: Miller WH]]
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[[Category: Payne, D.J.]]
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[[Category: Payne DJ]]
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[[Category: Qiu, X.]]
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[[Category: Qiu X]]
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[[Category: Seefeld, M.A.]]
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[[Category: Seefeld MA]]
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[[Category: 826]]
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[[Category: NAD]]
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[[Category: acp]]
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[[Category: antibiotic]]
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[[Category: enoyl reductase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:01:00 2007''
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Current revision

E. Coli Enoyl Reductase +NAD+SB385826

PDB ID 1i30

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