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1lb5

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{{Seed}}
 
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[[Image:1lb5.png|left|200px]]
 
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==TRAF6-RANK Complex==
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The line below this paragraph, containing "STRUCTURE_1lb5", creates the "Structure Box" on the page.
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<StructureSection load='1lb5' size='340' side='right'caption='[[1lb5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LB5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb5 OCA], [https://pdbe.org/1lb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lb5 RCSB], [https://www.ebi.ac.uk/pdbsum/1lb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb5 ProSAT]</span></td></tr>
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{{STRUCTURE_1lb5| PDB=1lb5 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRAF6_HUMAN TRAF6_HUMAN] E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.<ref>PMID:8837778</ref> <ref>PMID:11057907</ref> <ref>PMID:16378096</ref> <ref>PMID:17135271</ref> <ref>PMID:18093978</ref> <ref>PMID:18758450</ref> <ref>PMID:19675569</ref> <ref>PMID:19713527</ref> <ref>PMID:12140561</ref> <ref>PMID:19465916</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/1lb5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lb5 ConSurf].
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<div style="clear:both"></div>
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===TRAF6-RANK Complex===
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==See Also==
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*[[TNF receptor-associated factor 3D structures|TNF receptor-associated factor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12140561}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12140561 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_12140561}}
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==Disease==
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Known disease associated with this structure: Osteolysis, familial expansile OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]], Paget disease of bone OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603499 603499]]
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==About this Structure==
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1LB5 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB5 OCA].
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==Reference==
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Distinct molecular mechanism for initiating TRAF6 signalling., Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H, Nature. 2002 Jul 25;418(6896):443-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12140561 12140561]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Arron, J R.]]
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[[Category: Arron JR]]
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[[Category: Choi, Y.]]
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[[Category: Choi Y]]
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[[Category: Cirilli, M.]]
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[[Category: Cirilli M]]
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[[Category: Darnay, B G.]]
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[[Category: Darnay BG]]
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[[Category: Du, K.]]
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[[Category: Du K]]
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[[Category: Dzivenu, O.]]
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[[Category: Dzivenu O]]
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[[Category: Kobayashi, T.]]
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[[Category: Kobayashi T]]
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[[Category: Lamothe, B.]]
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[[Category: Lamothe B]]
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[[Category: Pike, J W.]]
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[[Category: Pike JW]]
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[[Category: Segal, D.]]
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[[Category: Segal D]]
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[[Category: Shevde, N K.]]
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[[Category: Shevde NK]]
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[[Category: Singh, S.]]
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[[Category: Singh S]]
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[[Category: Vologodskaia, M.]]
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[[Category: Vologodskaia M]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Ye, H.]]
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[[Category: Ye H]]
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[[Category: Yim, M.]]
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[[Category: Yim M]]
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[[Category: Traf6-rank complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:11:42 2008''
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Current revision

TRAF6-RANK Complex

PDB ID 1lb5

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