This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1lb7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:48, 29 November 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1lb7.png|left|200px]]
 
-
<!--
+
==IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1==
-
The line below this paragraph, containing "STRUCTURE_1lb7", creates the "Structure Box" on the page.
+
<StructureSection load='1lb7' size='340' side='right'caption='[[1lb7]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1lb7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LB7 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lb7 OCA], [https://pdbe.org/1lb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lb7 RCSB], [https://www.ebi.ac.uk/pdbsum/1lb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lb7 ProSAT]</span></td></tr>
-
{{STRUCTURE_1lb7| PDB=1lb7 | SCENE= }}
+
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
A panel of 22 naive peptide libraries was constructed in a polyvalent phage display format and sorted against insulin-like growth factor-1 (IGF-1). The libraries were pooled to achieve a total diversity of 4.4 x 10(11). After three rounds of selection, the majority of the phage clones bound specifically to IGF-1, with a disulfide-constrained CX(9)C scaffold dominating the selection. Four monovalently displayed sub-libraries were designed on the basis of these conserved motifs. Sub-library maturation in a monovalent format yielded an antagonistic peptide that inhibited the interactions between IGF-1 and two cell-surface receptors and those between IGF-1 and two soluble IGF binding proteins with micromolar potency. NMR analysis revealed that the peptide is highly structured in the absence of IGF-1, and peptides that preorganize the binding elements were selected during the sorting.
-
===IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1===
+
Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function.,Deshayes K, Schaffer ML, Skelton NJ, Nakamura GR, Kadkhodayan S, Sidhu SS Chem Biol. 2002 Apr;9(4):495-505. PMID:11983338<ref>PMID:11983338</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_11983338}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1lb7" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 11983338 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_11983338}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LB7 OCA].
+
[[Category: Deshayes K]]
-
 
+
[[Category: Kadkhodayan S]]
-
==Reference==
+
[[Category: Nakamura GR]]
-
Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function., Deshayes K, Schaffer ML, Skelton NJ, Nakamura GR, Kadkhodayan S, Sidhu SS, Chem Biol. 2002 Apr;9(4):495-505. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11983338 11983338]
+
[[Category: Schaffer ML]]
-
[[Category: Deshayes, K.]]
+
[[Category: Sidhu SS]]
-
[[Category: Kadkhodayan, S.]]
+
[[Category: Skelton NJ]]
-
[[Category: Nakamura, G R.]]
+
-
[[Category: Schaffer, M L.]]
+
-
[[Category: Sidhu, S S.]]
+
-
[[Category: Skelton, N J.]]
+
-
[[Category: Disulfide]]
+
-
[[Category: Loop-helix]]
+
-
[[Category: Peptide]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:12:35 2008''
+

Current revision

IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1

PDB ID 1lb7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1lb7"
Personal tools