1lcy

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{{Seed}}
 
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[[Image:1lcy.png|left|200px]]
 
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==Crystal Structure of the Mitochondrial Serine Protease HtrA2==
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The line below this paragraph, containing "STRUCTURE_1lcy", creates the "Structure Box" on the page.
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<StructureSection load='1lcy' size='340' side='right'caption='[[1lcy]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LCY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lcy OCA], [https://pdbe.org/1lcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lcy RCSB], [https://www.ebi.ac.uk/pdbsum/1lcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lcy ProSAT]</span></td></tr>
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{{STRUCTURE_1lcy| PDB=1lcy | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HTRA2_HUMAN HTRA2_HUMAN] Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:[https://omim.org/entry/610297 610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.<ref>PMID:15961413</ref> <ref>PMID:18401856</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HTRA2_HUMAN HTRA2_HUMAN] Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.<ref>PMID:15200957</ref> <ref>PMID:19502560</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lc/1lcy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lcy ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Mitochondrial Serine Protease HtrA2===
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==See Also==
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*[[Proteinase 3D structures|Proteinase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11967569}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11967569 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11967569}}
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==About this Structure==
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1LCY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LCY OCA].
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==Reference==
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Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi., Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y, Nat Struct Biol. 2002 Jun;9(6):436-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11967569 11967569]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Alnemri, E S.]]
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[[Category: Alnemri ES]]
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[[Category: Chai, J.]]
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[[Category: Chai J]]
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[[Category: Li, P.]]
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[[Category: Li P]]
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[[Category: Li, W.]]
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[[Category: Li W]]
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[[Category: Shi, Y.]]
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[[Category: Shi Y]]
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[[Category: Srinivasula, S M.]]
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[[Category: Srinivasula SM]]
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[[Category: Wu, J W.]]
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[[Category: Wu JW]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang Z]]
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[[Category: Apoptosis]]
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[[Category: Caspase activation]]
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[[Category: Iap-binding]]
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[[Category: Pdz domain]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:25:16 2008''
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Current revision

Crystal Structure of the Mitochondrial Serine Protease HtrA2

PDB ID 1lcy

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