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2a9l
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2a9l" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a9l" /> '''SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR T...) |
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| - | [[Image:2a9l.gif|left|200px]]<br /> | ||
| - | <applet load="2a9l" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2a9l" /> | ||
| - | '''SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE'''<br /> | ||
| - | == | + | ==SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE== |
| - | The structure of the bulge-helix-bulge motif that constitutes the | + | <StructureSection load='2a9l' size='340' side='right'caption='[[2a9l]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2a9l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A9L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9l OCA], [https://pdbe.org/2a9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a9l RCSB], [https://www.ebi.ac.uk/pdbsum/2a9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a9l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNATrp has been determined by NMR spectroscopy. The conformations of the two 3 nt bulges, where the pre-tRNA is cleaved, are stabilized by stacking interactions between bulge nucleotides and bases in the adjacent Watson-Crick helices and by a network of backbone hydrogen bonds. Both bulges are presented on the same minor groove face of the central 4 bp helix, and the overall structure has approximate two-fold symmetry, which makes it well-suited for attack by archaeal splicing endonucleases, which are symmetric dimers. | ||
| - | + | Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif.,Diener JL, Moore PB Mol Cell. 1998 May;1(6):883-94. PMID:9660971<ref>PMID:9660971</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2a9l" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Diener JL]] |
| - | [[Category: | + | [[Category: Moore PB]] |
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Current revision
SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE
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