2prb

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{{Seed}}
 
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[[Image:2prb.png|left|200px]]
 
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==crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A==
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The line below this paragraph, containing "STRUCTURE_2prb", creates the "Structure Box" on the page.
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<StructureSection load='2prb' size='340' side='right'caption='[[2prb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2prb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PRB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2pr8|2pr8]]</div></td></tr>
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{{STRUCTURE_2prb| PDB=2prb | SCENE= }}
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminoglycoside_N(6')-acetyltransferase Aminoglycoside N(6')-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.82 2.3.1.82] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2prb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2prb OCA], [https://pdbe.org/2prb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2prb RCSB], [https://www.ebi.ac.uk/pdbsum/2prb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2prb ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/2prb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2prb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The emergence of multi-resistant pathogenic bacteria is a worldwide health issue. Recently, clinical variants of a single antibiotic-modifying acetyltransferase, AAC(6')-Ib-a variant of aminoglycoside 6'-N-acetyltransferase-have been identified that confer extended resistance to most aminoglycosides and, more surprisingly, to structurally unrelated fluoroquinolones. The corresponding gene is carried by mobile genetic elements and is present in most multi-resistant pathogenic strains, hence making it a serious threat to current therapies. Here, we report the crystal structures of both narrow- and broad-spectrum resistance variants of this enzyme, which reveal the structural basis for the emergence of extended resistance. The active site shows an important plasticity and has adapted to new substrates by a large-scale gaping process. We have also obtained co-crystals with both substrates, and with a simple transition state analogue, which provides new clues for the design of inhibitors of this resistance mechanism.
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===crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A===
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Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance.,Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F EMBO Rep. 2008 Apr;9(4):344-9. Epub 2008 Feb 22. PMID:18292754<ref>PMID:18292754</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18292754}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2prb" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18292754 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18292754}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2PRB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PRB OCA].
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[[Category: Benas, P]]
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[[Category: Broutin, I]]
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==Reference==
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[[Category: Collatz, E]]
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Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance., Maurice F, Broutin I, Podglajen I, Benas P, Collatz E, Dardel F, EMBO Rep. 2008 Apr;9(4):344-349. Epub 2008 Feb 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18292754 18292754]
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[[Category: Dardel, F]]
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[[Category: Salmonella typhimurium]]
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[[Category: Maurice, F]]
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[[Category: Single protein]]
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[[Category: Podglajen, I]]
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[[Category: Benas, P.]]
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[[Category: Broutin, I.]]
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[[Category: Collatz, E.]]
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[[Category: Dardel, F.]]
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[[Category: Maurice, F.]]
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[[Category: Podglajen, I.]]
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[[Category: Aminoglycoside acetyltransferase]]
[[Category: Aminoglycoside acetyltransferase]]
[[Category: Gnat]]
[[Category: Gnat]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:24:11 2008''
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Current revision

crystal structure of aminoglycoside acetyltransferase AAC(6')-Ib in complex whith coenzyme A

PDB ID 2prb

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