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1lmw

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{{Seed}}
 
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[[Image:1lmw.png|left|200px]]
 
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<!--
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==LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone)==
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The line below this paragraph, containing "STRUCTURE_1lmw", creates the "Structure Box" on the page.
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<StructureSection load='1lmw' size='340' side='right'caption='[[1lmw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lmw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LMW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0GJ:L-ALPHA-GLUTAMYL-N-{(1S)-4-{[AMINO(IMINIO)METHYL]AMINO}-1-[(1S)-2-CHLORO-1-HYDROXYETHYL]BUTYL}GLYCINAMIDE'>0GJ</scene></td></tr>
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{{STRUCTURE_1lmw| PDB=1lmw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lmw OCA], [https://pdbe.org/1lmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lmw RCSB], [https://www.ebi.ac.uk/pdbsum/1lmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lmw ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/1lmw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lmw ConSurf].
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<div style="clear:both"></div>
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===LMW U-PA STRUCTURE COMPLEXED WITH EGRCMK (GLU-GLY-ARG CHLOROMETHYL KETONE)===
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_8591045}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8591045 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_8591045}}
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==About this Structure==
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1LMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LMW OCA].
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==Reference==
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The crystal structure of the catalytic domain of human urokinase-type plasminogen activator., Spraggon G, Phillips C, Nowak UK, Ponting CP, Saunders D, Dobson CM, Stuart DI, Jones EY, Structure. 1995 Jul 15;3(7):681-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8591045 8591045]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: U-plasminogen activator]]
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[[Category: Dobson CM]]
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[[Category: Dobson, C M.]]
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[[Category: Jones EY]]
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[[Category: Jones, E Y.]]
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[[Category: Nowak UK]]
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[[Category: Nowak, U K.]]
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[[Category: Phillips C]]
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[[Category: Phillips, C.]]
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[[Category: Ponting CP]]
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[[Category: Ponting, C P.]]
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[[Category: Saunders D]]
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[[Category: Saunders, D.]]
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[[Category: Spraggon GS]]
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[[Category: Spraggon, G S.]]
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[[Category: Stuart DI]]
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[[Category: Stuart, D I.]]
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[[Category: Fibrinolysis]]
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[[Category: Trypsin-like serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:27:32 2008''
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Current revision

LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone)

PDB ID 1lmw

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