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1lpw

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{{Seed}}
 
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[[Image:1lpw.png|left|200px]]
 
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==Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine==
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The line below this paragraph, containing "STRUCTURE_1lpw", creates the "Structure Box" on the page.
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<StructureSection load='1lpw' size='340' side='right'caption='[[1lpw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lpw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LPW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene></td></tr>
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{{STRUCTURE_1lpw| PDB=1lpw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lpw OCA], [https://pdbe.org/1lpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lpw RCSB], [https://www.ebi.ac.uk/pdbsum/1lpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lpw ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pairing of a consensus sequence of the precursor (pre)-mRNA intron with a short region of the U2 small nuclear (sn)RNA during assembly of the eukaryotic spliceosome results in formation of a complementary helix of seven base pairs with a single unpaired adenosine residue. The 2' OH of this adenosine, called the branch site, brings about nucleophilic attack at the pre-mRNA 5' splice site in the first step of splicing. Another feature of this pairing is the phylogenetic conservation of a pseudouridine (psi) residue in U2 snRNA nearly opposite the branch site. We show that the presence of this psi in the pre-mRNA branch-site helix of Saccharomyces cerevisiae induces a dramatically altered architectural landscape compared with that of its unmodified counterpart. The psi-induced structure places the nucleophile in an accessible position for the first step of splicing.
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===Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine===
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Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine.,Newby MI, Greenbaum NL Nat Struct Biol. 2002 Dec;9(12):958-65. PMID:12426583<ref>PMID:12426583</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12426583}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1lpw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12426583 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12426583}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LPW OCA].
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Greenbaum NL]]
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==Reference==
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[[Category: Newby MI]]
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Sculpting of the spliceosomal branch site recognition motif by a conserved pseudouridine., Newby MI, Greenbaum NL, Nat Struct Biol. 2002 Dec;9(12):958-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12426583 12426583]
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[[Category: Greenbaum, N L.]]
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[[Category: Newby, M I.]]
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[[Category: Branch site]]
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[[Category: Nmr]]
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[[Category: Pseudouridine]]
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[[Category: U2 snrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:45:59 2008''
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Current revision

Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine

PDB ID 1lpw

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