1lr0

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{{Seed}}
 
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[[Image:1lr0.png|left|200px]]
 
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==Pseudomonas aeruginosa TolA Domain III, Seleno-methionine Derivative==
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The line below this paragraph, containing "STRUCTURE_1lr0", creates the "Structure Box" on the page.
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<StructureSection load='1lr0' size='340' side='right'caption='[[1lr0]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LR0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.914&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1lr0| PDB=1lr0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lr0 OCA], [https://pdbe.org/1lr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lr0 RCSB], [https://www.ebi.ac.uk/pdbsum/1lr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lr0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TOLA_PSEAE TOLA_PSEAE] Involved in the TonB-independent uptake of proteins (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lr/1lr0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lr0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the C-terminal domain III of Pseudomonas aeruginosa TolA has been determined at 1.9 A resolution. The fold is similar to that of the corresponding domain of Escherichia coli TolA, despite the limited amino acid sequence identity of the two proteins (20%). A pattern was discerned that conserves the fold of domain III within the wider TolA family and, moreover, reveals a relationship between TolA domain III and the C-terminal domain of the TonB transporter proteins. We propose that the TolA and TonB C-terminal domains have a common evolutionary origin and are related by means of domain swapping, with interesting mechanistic implications. We have also determined the overall shape of the didomain, domains II + III, of P.aeruginosa TolA by solution X-ray scattering. The molecule is monomeric-its elongated, stalk shape can accommodate the crystal structure of domain III at one end, and an elongated helical bundle within the portion corresponding to domain II. Based on these data, a model for the periplasmic domains of P.aeruginosa TolA is presented that may explain the inferred allosteric properties of members of the TolA family. The mechanisms of TolA-mediated entry of bateriophages in P.aeruginosa and E.coli are likely to be similar.
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===Pseudomonas aeruginosa TolA Domain III, Seleno-methionine Derivative===
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Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein.,Witty M, Sanz C, Shah A, Grossmann JG, Mizuguchi K, Perham RN, Luisi B EMBO J. 2002 Aug 15;21(16):4207-18. PMID:12169623<ref>PMID:12169623</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1lr0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12169623}}, adds the Publication Abstract to the page
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*[[TolA|TolA]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12169623 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12169623}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1LR0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LR0 OCA].
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==Reference==
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Structure of the periplasmic domain of Pseudomonas aeruginosa TolA: evidence for an evolutionary relationship with the TonB transporter protein., Witty M, Sanz C, Shah A, Grossmann JG, Mizuguchi K, Perham RN, Luisi B, EMBO J. 2002 Aug 15;21(16):4207-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12169623 12169623]
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Grossman JG]]
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[[Category: Grossman, J G.]]
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[[Category: Luisi B]]
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[[Category: Luisi, B.]]
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[[Category: Mizuguchi K]]
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[[Category: Mizuguchi, K.]]
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[[Category: Perham RN]]
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[[Category: Perham, R N.]]
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[[Category: Sanz C]]
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[[Category: Sanz, C.]]
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[[Category: Shah A]]
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[[Category: Shah, A.]]
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[[Category: Witty M]]
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[[Category: Witty, M.]]
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[[Category: Domain-swapping]]
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[[Category: Tola]]
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[[Category: Tonb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:50:30 2008''
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Current revision

Pseudomonas aeruginosa TolA Domain III, Seleno-methionine Derivative

PDB ID 1lr0

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