1ls5

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{{Seed}}
 
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[[Image:1ls5.png|left|200px]]
 
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==Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A==
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The line below this paragraph, containing "STRUCTURE_1ls5", creates the "Structure Box" on the page.
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<StructureSection load='1ls5' size='340' side='right'caption='[[1ls5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ls5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jgf 1jgf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LS5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
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{{STRUCTURE_1ls5| PDB=1ls5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ls5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ls5 OCA], [https://pdbe.org/1ls5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ls5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ls5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ls5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLM4_PLAF7 PLM4_PLAF7] During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).[UniProtKB:Q17SB3]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ls/1ls5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ls5 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF PLASMEPSIN IV FROM P. FALCIPARUM IN COMPLEX WITH PEPSTATIN A===
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==See Also==
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*[[Plasmepsin|Plasmepsin]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12614616}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12614616 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12614616}}
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==About this Structure==
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1LS5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jgf 1jgf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LS5 OCA].
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==Reference==
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Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum., Asojo OA, Gulnik SV, Afonina E, Yu B, Ellman JA, Haque TS, Silva AM, J Mol Biol. 2003 Mar 14;327(1):173-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12614616 12614616]
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[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Single protein]]
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[[Category: Streptomyces argenteolus subsp. toyonakensis]]
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[[Category: Afonina, E.]]
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[[Category: Afonina E]]
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[[Category: Asojo, O A.]]
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[[Category: Asojo OA]]
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[[Category: Ellman, J A.]]
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[[Category: Ellman JA]]
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[[Category: Gulnik, S V.]]
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[[Category: Gulnik SV]]
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[[Category: Haque, T S.]]
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[[Category: Haque TS]]
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[[Category: Silva, A M.]]
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[[Category: Silva AM]]
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[[Category: Yu, B.]]
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[[Category: Yu B]]
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[[Category: Eukaryotic aspartic proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:58:32 2008''
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Current revision

Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A

PDB ID 1ls5

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