1lu8

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{{Seed}}
 
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[[Image:1lu8.png|left|200px]]
 
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==Solution structure of GsMTx-4==
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The line below this paragraph, containing "STRUCTURE_1lu8", creates the "Structure Box" on the page.
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<StructureSection load='1lu8' size='340' side='right'caption='[[1lu8]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Grammostola_rosea Grammostola rosea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LU8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1lu8| PDB=1lu8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lu8 OCA], [https://pdbe.org/1lu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lu8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lu8 ProSAT]</span></td></tr>
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</table>
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===Solution structure of GsMTx-4===
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== Function ==
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[https://www.uniprot.org/uniprot/MTX4_GRARO MTX4_GRARO] This cationic hydrophobic peptide inhibits a lot of different channels and has an antimicrobial activity. It blocks mechanosensitive ion channels (also named stretch-activated channels or SACs), without having effect on whole-cell voltage-sensitive currents. Acts by partitioning into the membrane and perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. Inhibits atrial fibrillation as well as the membrane motor of outer hair cells at low doses. It also binds to the voltage sensor of voltage-gated potassium channels from the archaebacterium Aeropyrum pernix (KvAP) without affecting channel gating. It has also a medium toxicity on a large spectra of sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.7/SCN9A), and also inhibits potassium channels Kv11.1/KCNH2 and Kv11.2/KCNH6. It also exhibits antimicrobial activities against the Gram-positive bacteria B.subtilis (MIC=0.5 uM), S.aureus (MIC=2-4 uM), and S.epidermidis (MIC=4-8 uM), and Gram-negative bacteria S.typhimurium (MIC=32.64 uM), P.aeruginosa (MIC=8-16 uM), and E.coli (MIC=8-16 uM).<ref>PMID:10779316</ref> <ref>PMID:11343101</ref> <ref>PMID:15241420</ref> <ref>PMID:15287735</ref> <ref>PMID:16376854</ref> <ref>PMID:16797839</ref> <ref>PMID:17384064</ref> <ref>PMID:17573432</ref> <ref>PMID:19955179</ref>
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== References ==
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==About this Structure==
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<references/>
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1LU8 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LU8 OCA].
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Earm, Y E.]]
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[[Category: Grammostola rosea]]
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[[Category: Jung, H J.]]
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[[Category: Large Structures]]
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[[Category: Kim, J I.]]
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[[Category: Earm YE]]
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[[Category: Lee, C W.]]
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[[Category: Jung HJ]]
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[[Category: Inhibitory cystine knot]]
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[[Category: Kim JI]]
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[[Category: Triple stranded antiparellel beta-sheet]]
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[[Category: Lee CW]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:14:02 2008''
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Current revision

Solution structure of GsMTx-4

PDB ID 1lu8

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