1luf

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{{Seed}}
 
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[[Image:1luf.png|left|200px]]
 
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==Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation==
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The line below this paragraph, containing "STRUCTURE_1luf", creates the "Structure Box" on the page.
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<StructureSection load='1luf' size='340' side='right'caption='[[1luf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1luf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1luf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1luf OCA], [https://pdbe.org/1luf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1luf RCSB], [https://www.ebi.ac.uk/pdbsum/1luf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1luf ProSAT]</span></td></tr>
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{{STRUCTURE_1luf| PDB=1luf | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MUSK_RAT MUSK_RAT] Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation.<ref>PMID:16870737</ref> <ref>PMID:17011580</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/1luf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1luf ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation===
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==See Also==
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*[[Tyrosine kinase receptor 3D structures|Tyrosine kinase receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12220490 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12220490}}
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==About this Structure==
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1LUF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUF OCA].
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==Reference==
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Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation., Till JH, Becerra M, Watty A, Lu Y, Ma Y, Neubert TA, Burden SJ, Hubbard SR, Structure. 2002 Sep;10(9):1187-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12220490 12220490]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Becerra M]]
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[[Category: Transferase]]
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[[Category: Burden SJ]]
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[[Category: Becerra, M.]]
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[[Category: Hubbard SR]]
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[[Category: Burden, S J.]]
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[[Category: Lu Y]]
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[[Category: Hubbard, S R.]]
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[[Category: Ma Y]]
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[[Category: Lu, Y.]]
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[[Category: Neubert TA]]
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[[Category: Ma, Y.]]
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[[Category: Till JH]]
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[[Category: Neubert, T A.]]
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[[Category: Watty A]]
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[[Category: Till, J H.]]
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[[Category: Watty, A.]]
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[[Category: Mass spectrometry]]
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[[Category: Phosphorylation]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:17:27 2008''
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Current revision

Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation

PDB ID 1luf

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