1lwr

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{{Seed}}
 
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[[Image:1lwr.png|left|200px]]
 
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==Solution structure of the NCAM fibronectin type III module 2==
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The line below this paragraph, containing "STRUCTURE_1lwr", creates the "Structure Box" on the page.
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<StructureSection load='1lwr' size='340' side='right'caption='[[1lwr]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LWR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lwr OCA], [https://pdbe.org/1lwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lwr RCSB], [https://www.ebi.ac.uk/pdbsum/1lwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lwr ProSAT]</span></td></tr>
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{{STRUCTURE_1lwr| PDB=1lwr | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAM1_RAT NCAM1_RAT] This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/1lwr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lwr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The neural cell adhesion molecule (NCAM) promotes axonal outgrowth, presumably through an interaction with the fibroblast growth factor receptor (FGFR). NCAM also has a little-understood ATPase activity. We here demonstrate for the first time a direct interaction between NCAM (fibronectin type III [F3] modules 1 and 2) and FGFR1 (Ig modules 2 and 3) by surface plasmon resonance (SPR) analysis. The structure of the NCAM F3 module 2 was determined by NMR and the module was shown by NMR to interact with the FGFR1 Ig module 3 and ATP. The NCAM sites binding to FGFR and ATP were found to overlap and ATP was shown by SPR to inhibit the NCAM-FGFR binding, indicating that ATP probably regulates the NCAM-FGFR interaction. Furthermore, we demonstrate that the NCAM module was able to induce activation (phosphorylation) of FGFR and to stimulate neurite outgrowth. In contrast, ATP inhibited neurite outgrowth induced by the module.
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===Solution structure of the NCAM fibronectin type III module 2===
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Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP.,Kiselyov VV, Skladchikova G, Hinsby AM, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Poulsen FM, Berezin V, Bock E Structure. 2003 Jun;11(6):691-701. PMID:12791257<ref>PMID:12791257</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12791257}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1lwr" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12791257 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12791257}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1LWR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LWR OCA].
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==Reference==
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Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP., Kiselyov VV, Skladchikova G, Hinsby AM, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Poulsen FM, Berezin V, Bock E, Structure. 2003 Jun;11(6):691-701. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12791257 12791257]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Berezin V]]
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[[Category: Berezin, V.]]
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[[Category: Bock E]]
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[[Category: Bock, E.]]
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[[Category: Hinsby AM]]
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[[Category: Hinsby, A M.]]
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[[Category: Jensen PH]]
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[[Category: Jensen, P H.]]
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[[Category: Kiselyov VV]]
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[[Category: Kiselyov, V V.]]
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[[Category: Kulahin N]]
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[[Category: Kulahin, N.]]
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[[Category: Pedersen N]]
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[[Category: Pedersen, N.]]
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[[Category: Poulsen FM]]
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[[Category: Poulsen, F M.]]
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[[Category: Skladchikova G]]
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[[Category: Skladchikova, G.]]
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[[Category: Tsetlin V]]
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[[Category: Tsetlin, V.]]
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[[Category: All beta]]
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[[Category: Fibronectin type iii module]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:43:15 2008''
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Current revision

Solution structure of the NCAM fibronectin type III module 2

PDB ID 1lwr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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