1ly1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:37, 14 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ly1.png|left|200px]]
 
-
<!--
+
==Structure and Mechanism of T4 Polynucleotide Kinase==
-
The line below this paragraph, containing "STRUCTURE_1ly1", creates the "Structure Box" on the page.
+
<StructureSection load='1ly1' size='340' side='right'caption='[[1ly1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ly1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LY1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LY1 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1ly1| PDB=1ly1 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ly1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ly1 OCA], [https://pdbe.org/1ly1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ly1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ly1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ly1 ProSAT]</span></td></tr>
-
 
+
</table>
-
===Structure and Mechanism of T4 Polynucleotide Kinase===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/KIPN_BPT4 KIPN_BPT4] Acts as a 5'-hydroxyl kinase, a 3'-phosphatase and a 2',3'-cyclic phosphodiesterase. Catalyzes the transfer of the terminal phosphate of ATP to the 5'-hydroxyl termini of ribo- and deoxyribonucleotides. In the presence of ADP the enzyme also catalyzes an exchange reaction. In the exchange reaction, an excess ADP causes the enzyme to transfer the 5' terminal phosphate from phosphorylated DNA to ADP. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase.
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_12110598}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12110598 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ly/1ly1_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_12110598}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1LY1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LY1 OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ly1 ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme., Wang LK, Lima CD, Shuman S, EMBO J. 2002 Jul 15;21(14):3873-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12110598 12110598]
+
</StructureSection>
-
[[Category: Enterobacteria phage t4]]
+
[[Category: Escherichia virus T4]]
-
[[Category: Polynucleotide 5'-hydroxy-kinase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Lima CD]]
-
[[Category: Lima, C D.]]
+
[[Category: Shuman S]]
-
[[Category: Shuman, S.]]
+
[[Category: Wang LK]]
-
[[Category: Wang, L K.]]
+
-
[[Category: Kinase]]
+
-
[[Category: Phage]]
+
-
[[Category: Phosphatase]]
+
-
[[Category: Pnk]]
+
-
[[Category: Polynucleotide]]
+
-
[[Category: T4]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:47:40 2008''
+

Current revision

Structure and Mechanism of T4 Polynucleotide Kinase

PDB ID 1ly1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ly1"
Personal tools