1m1a

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{{Seed}}
 
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[[Image:1m1a.png|left|200px]]
 
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==LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA==
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The line below this paragraph, containing "STRUCTURE_1m1a", creates the "Structure Box" on the page.
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<StructureSection load='1m1a' size='340' side='right'caption='[[1m1a]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m1a]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M1A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BAL:BETA-ALANINE'>BAL</scene>, <scene name='pdbligand=DIB:3-AMINO-(DIMETHYLPROPYLAMINE)'>DIB</scene>, <scene name='pdbligand=IMT:4-AMINO-(1-METHYLIMIDAZOLE)-2-CARBOXYLIC+ACID'>IMT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYB:4-AMINO-(1-METHYLPYRROLE)-2-CARBOXYLIC+ACID'>PYB</scene></td></tr>
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{{STRUCTURE_1m1a| PDB=1m1a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m1a OCA], [https://pdbe.org/1m1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m1a RCSB], [https://www.ebi.ac.uk/pdbsum/1m1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m1a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H3C_XENLA H3C_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m1a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m1a ConSurf].
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<div style="clear:both"></div>
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===LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA===
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12559907 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12559907}}
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==About this Structure==
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1M1A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M1A OCA].
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==Reference==
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Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands., Suto RK, Edayathumangalam RS, White CL, Melander C, Gottesfeld JM, Dervan PB, Luger K, J Mol Biol. 2003 Feb 14;326(2):371-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12559907 12559907]
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[[Category: Protein complex]]
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[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Dervan, P B.]]
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[[Category: Dervan PB]]
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[[Category: Edayathumangalam, R S.]]
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[[Category: Edayathumangalam RS]]
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[[Category: Gottesfeld, J M.]]
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[[Category: Gottesfeld JM]]
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[[Category: Luger, K.]]
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[[Category: Luger K]]
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[[Category: Melander, C.]]
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[[Category: Melander C]]
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[[Category: Suto, R K.]]
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[[Category: Suto RK]]
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[[Category: White, C L.]]
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[[Category: White CL]]
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[[Category: Chromatin]]
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[[Category: Chromatin remodeling]]
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[[Category: Dna regognition]]
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[[Category: Histone]]
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[[Category: Nucleosome]]
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[[Category: Pyrrole-imidazole polyamide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:59:53 2008''
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Current revision

LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA

PDB ID 1m1a

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