1m2o

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{{Seed}}
 
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[[Image:1m2o.png|left|200px]]
 
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==Crystal Structure of the Sec23-Sar1 complex==
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The line below this paragraph, containing "STRUCTURE_1m2o", creates the "Structure Box" on the page.
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<StructureSection load='1m2o' size='340' side='right'caption='[[1m2o]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m2o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2O FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1m2o| PDB=1m2o | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2o OCA], [https://pdbe.org/1m2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2o RCSB], [https://www.ebi.ac.uk/pdbsum/1m2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2o ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEC23_YEAST SEC23_YEAST] Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SEC23 interacts with BET3 in order to target TRAPPI complex to COPII involved in internalisation of plasma membrane proteins like the maltose transporter.<ref>PMID:2670558</ref> <ref>PMID:6996832</ref> <ref>PMID:7026045</ref> <ref>PMID:3293799</ref> <ref>PMID:3049622</ref> <ref>PMID:2188733</ref> <ref>PMID:1498369</ref> <ref>PMID:7925484</ref> <ref>PMID:8451644</ref> <ref>PMID:8548805</ref> <ref>PMID:8909535</ref> <ref>PMID:9427388</ref> <ref>PMID:9023343</ref> <ref>PMID:9624457</ref> <ref>PMID:9428766</ref> <ref>PMID:10198022</ref> <ref>PMID:11086000</ref> <ref>PMID:10720463</ref> <ref>PMID:12941276</ref> <ref>PMID:14627716</ref> <ref>PMID:16269340</ref> <ref>PMID:17287728</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m2o_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m2o ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Sec23-Sar1 complex===
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==See Also==
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12239560 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12239560}}
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==About this Structure==
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1M2O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2O OCA].
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==Reference==
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Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat., Bi X, Corpina RA, Goldberg J, Nature. 2002 Sep 19;419(6904):271-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12239560 12239560]
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[[Category: Protein complex]]
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Bi, X.]]
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[[Category: Bi X]]
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[[Category: Corpina, R A.]]
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[[Category: Corpina RA]]
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[[Category: Goldberg, J.]]
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[[Category: Goldberg J]]
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[[Category: Beta barrel]]
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[[Category: Gelsolin domain]]
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[[Category: Vwa domain]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:05:20 2008''
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Current revision

Crystal Structure of the Sec23-Sar1 complex

PDB ID 1m2o

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