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1m2r

From Proteopedia

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{{Seed}}
 
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[[Image:1m2r.png|left|200px]]
 
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<!--
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==Crystal structure of 5,8-di-amino-1,4-di-hydroxy-anthraquinone/CK2 kinase complex==
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The line below this paragraph, containing "STRUCTURE_1m2r", creates the "Structure Box" on the page.
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<StructureSection load='1m2r' size='340' side='right'caption='[[1m2r]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M2R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MNY:5,8-DI-AMINO-1,4-DIHYDROXY-ANTHRAQUINONE'>MNY</scene></td></tr>
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{{STRUCTURE_1m2r| PDB=1m2r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2r OCA], [https://pdbe.org/1m2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m2r RCSB], [https://www.ebi.ac.uk/pdbsum/1m2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m2r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSK2A_MAIZE CSK2A_MAIZE] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/1m2r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m2r ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of 5,8-di-amino-1,4-di-hydroxy-anthraquinone/CK2 kinase complex===
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==See Also==
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12419810}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12419810 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12419810}}
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==About this Structure==
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1M2R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2R OCA].
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==Reference==
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Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight., De Moliner E, Moro S, Sarno S, Zagotto G, Zanotti G, Pinna LA, Battistutta R, J Biol Chem. 2003 Jan 17;278(3):1831-6. Epub 2002 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12419810 12419810]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Single protein]]
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[[Category: Zea mays]]
[[Category: Zea mays]]
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[[Category: Battistutta, R.]]
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[[Category: Battistutta R]]
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[[Category: Moliner, E De.]]
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[[Category: De Moliner E]]
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[[Category: Moro, S.]]
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[[Category: Moro S]]
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[[Category: Pinna, L A.]]
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[[Category: Pinna LA]]
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[[Category: Sarno, S.]]
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[[Category: Sarno S]]
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[[Category: Zagotto, G.]]
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[[Category: Zagotto G]]
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[[Category: Zanotti, G.]]
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[[Category: Zanotti G]]
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[[Category: Inhibitor-enzyme complex]]
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[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:05:28 2008''
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Current revision

Crystal structure of 5,8-di-amino-1,4-di-hydroxy-anthraquinone/CK2 kinase complex

PDB ID 1m2r

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