1m35

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{{Seed}}
 
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[[Image:1m35.png|left|200px]]
 
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==Aminopeptidase P from Escherichia coli==
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The line below this paragraph, containing "STRUCTURE_1m35", creates the "Structure Box" on the page.
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<StructureSection load='1m35' size='340' side='right'caption='[[1m35]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m35]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M35 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_1m35| PDB=1m35 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m35 OCA], [https://pdbe.org/1m35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m35 RCSB], [https://www.ebi.ac.uk/pdbsum/1m35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m35 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPP_ECOLI AMPP_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/1m35_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m35 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Aminopeptidase P (AMPP) from Escherichia coli cleaves the N-terminal residue from an oligopeptide if the second residue is proline. The active site contains a dinuclear metal centre. Following earlier structural analyses of crystals in space groups P6(4)22 and I4(1)22, the structure of AMPP has been solved and refined in the orthorhombic space group C222(1) at 2.4 A resolution. There are six subunits in the asymmetric unit. These are arranged in two types of tetramer. One tetramer comprises four crystallographically independent subunits, while the other comprises two pairs of subunits related by a crystallographic twofold axis. The final model of 20 994 protein atoms, 1618 water molecules and 12 metal atoms refined to residuals R = 0.195 and R(free) = 0.215. The molecular structure confirms most of the previously reported features, including the subunit-subunit interfaces in the tetramer and persistent disorder at some residues. The metal-ligand bond lengths at the active site suggest that one of the two Mn atoms is five-coordinate rather than six-coordinate.
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===Aminopeptidase P from Escherichia coli===
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An orthorhombic form of Escherichia coli aminopeptidase P at 2.4 A resolution.,Graham SC, Lee M, Freeman HC, Guss JM Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):897-902. Epub 2003, Apr 25. PMID:12777807<ref>PMID:12777807</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1m35" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12777807}}, adds the Publication Abstract to the page
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12777807 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12777807}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1M35 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M35 OCA].
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==Reference==
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An orthorhombic form of Escherichia coli aminopeptidase P at 2.4 A resolution., Graham SC, Lee M, Freeman HC, Guss JM, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):897-902. Epub 2003, Apr 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12777807 12777807]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Xaa-Pro aminopeptidase]]
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[[Category: Freeman HC]]
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[[Category: Freeman, H C.]]
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[[Category: Graham SC]]
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[[Category: Graham, S C.]]
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[[Category: Guss JM]]
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[[Category: Guss, J M.]]
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[[Category: Lee M]]
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[[Category: Lee, M.]]
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[[Category: Aminopeptidase]]
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[[Category: Manganese enzyme]]
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[[Category: Proline specific]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:07:14 2008''
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Current revision

Aminopeptidase P from Escherichia coli

PDB ID 1m35

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