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1m4m

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{{Seed}}
 
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[[Image:1m4m.png|left|200px]]
 
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<!--
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==Mouse Survivin==
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The line below this paragraph, containing "STRUCTURE_1m4m", creates the "Structure Box" on the page.
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<StructureSection load='1m4m' size='340' side='right'caption='[[1m4m]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1m4m| PDB=1m4m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4m OCA], [https://pdbe.org/1m4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4m RCSB], [https://www.ebi.ac.uk/pdbsum/1m4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BIRC5_MOUSE BIRC5_MOUSE] Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. May counteract a default induction of apoptosis in G2/M phase. The acetylated form represses STAT3 transactivation of target gene promoters. May play a role in neoplasia. Inhibitor of CASP3 and CASP7 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4m ConSurf].
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<div style="clear:both"></div>
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===Mouse Survivin===
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==See Also==
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*[[Survivin|Survivin]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_10949038}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10949038 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10949038}}
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==About this Structure==
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1M4M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4M OCA].
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==Reference==
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Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin., Muchmore SW, Chen J, Jakob C, Zakula D, Matayoshi ED, Wu W, Zhang H, Li F, Ng SC, Altieri DC, Mol Cell. 2000 Jul;6(1):173-82. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10949038 10949038]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Altieri DC]]
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[[Category: Altieri, D C.]]
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[[Category: Chen J]]
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[[Category: Chen, J.]]
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[[Category: Jakob C]]
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[[Category: Jakob, C.]]
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[[Category: Li F]]
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[[Category: Li, F.]]
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[[Category: Matayoshi ED]]
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[[Category: Matayoshi, E D.]]
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[[Category: Muchmore SW]]
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[[Category: Muchmore, S W.]]
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[[Category: Ng SC]]
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[[Category: Ng, S C.]]
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[[Category: Wu W]]
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[[Category: Wu, W.]]
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[[Category: Zakula D]]
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[[Category: Zakula, D.]]
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[[Category: Zhang H]]
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[[Category: Zhang, H.]]
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[[Category: Zn finger baculovirus iap repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:12:02 2008''
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Current revision

Mouse Survivin

PDB ID 1m4m

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