1m6d

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{{Seed}}
 
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[[Image:1m6d.png|left|200px]]
 
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==Crystal structure of human cathepsin F==
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The line below this paragraph, containing "STRUCTURE_1m6d", creates the "Structure Box" on the page.
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<StructureSection load='1m6d' size='340' side='right'caption='[[1m6d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m6d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M6D FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYP:4-MORPHOLIN-4-YL-PIPERIDINE-1-CARBOXYLIC+ACID+[1-(3-BENZENESULFONYL-1-PROPYL-ALLYLCARBAMOYL)-2-PHENYLETHYL]-AMIDE'>MYP</scene></td></tr>
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{{STRUCTURE_1m6d| PDB=1m6d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6d OCA], [https://pdbe.org/1m6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m6d RCSB], [https://www.ebi.ac.uk/pdbsum/1m6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m6d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATF_HUMAN CATF_HUMAN] Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m6d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m6d ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cathepsin F is a lysosomal cysteine protease of the papain family, and likely plays a regulatory role in processing the invariant chain that is associated with the major histocompatibility complex (MHC) class II. Evidence suggests that inhibiting cathepsin F activity will block MHC class II processing in macrophages. Consequently, inhibitors of this enzyme may be useful in treating certain diseases that involve an inappropriate or excessive immune response. We have determined the 1.7A structure of the mature domain of human cathepsin F associated with an irreversible vinyl sulfone inhibitor. This structure provides a basis for understanding cathepsin F's substrate specificity, and suggests ways of identifying potent and selective inhibitors of this enzyme.
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===Crystal structure of human cathepsin F===
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The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators.,Somoza JR, Palmer JT, Ho JD J Mol Biol. 2002 Sep 20;322(3):559-68. PMID:12225749<ref>PMID:12225749</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1m6d" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12225749}}, adds the Publication Abstract to the page
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12225749 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12225749}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1M6D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6D OCA].
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==Reference==
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The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators., Somoza JR, Palmer JT, Ho JD, J Mol Biol. 2002 Sep 20;322(3):559-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12225749 12225749]
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[[Category: Cathepsin F]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ho, J D.]]
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[[Category: Ho JD]]
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[[Category: Palmer, J T.]]
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[[Category: Palmer JT]]
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[[Category: Somoza, J R.]]
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[[Category: Somoza JR]]
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[[Category: Papain family cysteine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:18:53 2008''
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Current revision

Crystal structure of human cathepsin F

PDB ID 1m6d

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