1m6i

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{{Seed}}
 
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[[Image:1m6i.png|left|200px]]
 
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==Crystal Structure of Apoptosis Inducing Factor (AIF)==
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The line below this paragraph, containing "STRUCTURE_1m6i", creates the "Structure Box" on the page.
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<StructureSection load='1m6i' size='340' side='right'caption='[[1m6i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m6i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M6I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
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{{STRUCTURE_1m6i| PDB=1m6i | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6i OCA], [https://pdbe.org/1m6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m6i RCSB], [https://www.ebi.ac.uk/pdbsum/1m6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m6i ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/AIFM1_HUMAN AIFM1_HUMAN] Defects in AIFM1 are the cause of combined oxidative phosphorylation deficiency type 6 (COXPD6) [MIM:[https://omim.org/entry/300816 300816]. It is a mitochondrial disease resulting in a neurodegenerative disorder characterized by psychomotor delay, hypotonia, areflexia, muscle weakness and wasting.<ref>PMID:20362274</ref> <ref>PMID:22019070</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/AIFM1_HUMAN AIFM1_HUMAN] Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.<ref>PMID:17094969</ref> <ref>PMID:19418225</ref> <ref>PMID:20362274</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/1m6i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m6i ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Apoptosis Inducing Factor (AIF)===
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==See Also==
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12198487}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12198487 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12198487}}
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==About this Structure==
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1M6I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6I OCA].
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==Reference==
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DNA binding is required for the apoptogenic action of apoptosis inducing factor., Ye H, Cande C, Stephanou NC, Jiang S, Gurbuxani S, Larochette N, Daugas E, Garrido C, Kroemer G, Wu H, Nat Struct Biol. 2002 Sep;9(9):680-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198487 12198487]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cande, C.]]
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[[Category: Cande C]]
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[[Category: Daugas, E.]]
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[[Category: Daugas E]]
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[[Category: Garrido, C.]]
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[[Category: Garrido C]]
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[[Category: Gurbuxani, S.]]
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[[Category: Gurbuxani S]]
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[[Category: Jiang, S.]]
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[[Category: Jiang S]]
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[[Category: Kroemer, G.]]
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[[Category: Kroemer G]]
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[[Category: Larochette, N.]]
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[[Category: Larochette N]]
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[[Category: Stephanou, N C.]]
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[[Category: Stephanou NC]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Ye, H.]]
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[[Category: Ye H]]
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[[Category: Aif]]
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[[Category: Apoptosis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:19:23 2008''
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Current revision

Crystal Structure of Apoptosis Inducing Factor (AIF)

PDB ID 1m6i

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