1m7w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:41, 14 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1m7w.png|left|200px]]
 
-
<!--
+
==HNF4a ligand binding domain with bound fatty acid==
-
The line below this paragraph, containing "STRUCTURE_1m7w", creates the "Structure Box" on the page.
+
<StructureSection load='1m7w' size='340' side='right'caption='[[1m7w]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1m7w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M7W FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene></td></tr>
-
{{STRUCTURE_1m7w| PDB=1m7w | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m7w OCA], [https://pdbe.org/1m7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m7w RCSB], [https://www.ebi.ac.uk/pdbsum/1m7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m7w ProSAT]</span></td></tr>
-
 
+
</table>
-
===HNF4a ligand binding domain with bound fatty acid===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/HNF4A_RAT HNF4A_RAT] Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_12193589}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 12193589 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m7/1m7w_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_12193589}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1M7W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M7W OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m7w ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand., Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE, J Biol Chem. 2002 Oct 11;277(41):37973-6. Epub 2002 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12193589 12193589]
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Rattus rattus]]
[[Category: Rattus rattus]]
-
[[Category: Single protein]]
+
[[Category: Chi YI]]
-
[[Category: Chi, Y I.]]
+
[[Category: Dhe-Paganon S]]
-
[[Category: Dhe-Paganon, S.]]
+
[[Category: Duda K]]
-
[[Category: Duda, K.]]
+
[[Category: Iwamoto M]]
-
[[Category: Iwamoto, M.]]
+
[[Category: Shoelson SE]]
-
[[Category: Shoelson, S E.]]
+
-
[[Category: Transcription factor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:24:31 2008''
+

Current revision

HNF4a ligand binding domain with bound fatty acid

PDB ID 1m7w

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m7w"
Personal tools