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1m8a

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{{Seed}}
 
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[[Image:1m8a.png|left|200px]]
 
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<!--
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==Human MIP-3alpha/CCL20==
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The line below this paragraph, containing "STRUCTURE_1m8a", creates the "Structure Box" on the page.
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<StructureSection load='1m8a' size='340' side='right'caption='[[1m8a]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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{{STRUCTURE_1m8a| PDB=1m8a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8a OCA], [https://pdbe.org/1m8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8a RCSB], [https://www.ebi.ac.uk/pdbsum/1m8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8a ProSAT]</span></td></tr>
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</table>
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===Human MIP-3alpha/CCL20===
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== Function ==
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[https://www.uniprot.org/uniprot/CCL20_HUMAN CCL20_HUMAN] Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.<ref>PMID:12149255</ref>
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12149255}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12149255 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m8/1m8a_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12149255}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1M8A is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8A OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m8a ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The structure of human macrophage inflammatory protein-3alpha /CCL20. Linking antimicrobial and CC chemokine receptor-6-binding activities with human beta-defensins., Hoover DM, Boulegue C, Yang D, Oppenheim JJ, Tucker K, Lu W, Lubkowski J, J Biol Chem. 2002 Oct 4;277(40):37647-54. Epub 2002 Jul 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12149255 12149255]
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<references/>
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[[Category: Single protein]]
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__TOC__
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[[Category: Boulegue, C.]]
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</StructureSection>
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[[Category: Hoover, D M.]]
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[[Category: Homo sapiens]]
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[[Category: Lu, W.]]
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[[Category: Large Structures]]
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[[Category: Lubkowski, J.]]
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[[Category: Boulegue C]]
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[[Category: Oppenheim, J J.]]
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[[Category: Hoover DM]]
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[[Category: Tucker, K.]]
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[[Category: Lu W]]
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[[Category: Yang, D.]]
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[[Category: Lubkowski J]]
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[[Category: Cc-chemokine]]
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[[Category: Oppenheim JJ]]
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[[Category: Il-8 type dimer]]
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[[Category: Tucker K]]
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[[Category: Yang D]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:25:19 2008''
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Current revision

Human MIP-3alpha/CCL20

PDB ID 1m8a

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