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1m93

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{{Seed}}
 
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[[Image:1m93.png|left|200px]]
 
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==1.65 A Structure of Cleaved Viral Serpin CRMA==
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The line below this paragraph, containing "STRUCTURE_1m93", creates the "Structure Box" on the page.
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<StructureSection load='1m93' size='340' side='right'caption='[[1m93]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1m93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M93 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_1m93| PDB=1m93 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m93 OCA], [https://pdbe.org/1m93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m93 RCSB], [https://www.ebi.ac.uk/pdbsum/1m93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m93 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPI2_CWPXB SPI2_CWPXB] Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a "cross-class" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B.<ref>PMID:1339309</ref> <ref>PMID:8034697</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m9/1m93_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m93 ConSurf].
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<div style="clear:both"></div>
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===1.65 A Structure of Cleaved Viral Serpin CRMA===
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==See Also==
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*[[Serpin 3D structures|Serpin 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10975564}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10975564 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_10975564}}
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==About this Structure==
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1M93 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Cowpox_virus Cowpox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M93 OCA].
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==Reference==
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Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition., Simonovic M, Gettins PGW, Volz K, Protein Sci. 2000 Aug;9(8):1423-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10975564 10975564]
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[[Category: Cowpox virus]]
[[Category: Cowpox virus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Gettins, P G.W.]]
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[[Category: Gettins PGW]]
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[[Category: Simonovic, M.]]
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[[Category: Simonovic M]]
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[[Category: Volz, K.]]
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[[Category: Volz K]]
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[[Category: Apoptosis]]
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[[Category: Crma]]
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[[Category: Ice inhibitor]]
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[[Category: Serpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:28:22 2008''
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Current revision

1.65 A Structure of Cleaved Viral Serpin CRMA

PDB ID 1m93

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