1maz

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{{Seed}}
 
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[[Image:1maz.png|left|200px]]
 
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==X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH==
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The line below this paragraph, containing "STRUCTURE_1maz", creates the "Structure Box" on the page.
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<StructureSection load='1maz' size='340' side='right'caption='[[1maz]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1maz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MAZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1maz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1maz OCA], [https://pdbe.org/1maz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1maz RCSB], [https://www.ebi.ac.uk/pdbsum/1maz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1maz ProSAT]</span></td></tr>
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{{STRUCTURE_1maz| PDB=1maz | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ma/1maz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1maz ConSurf].
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<div style="clear:both"></div>
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===X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_8692274}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8692274 is the PubMed ID number.
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</StructureSection>
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[[Category: Homo sapiens]]
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{{ABSTRACT_PUBMED_8692274}}
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[[Category: Large Structures]]
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[[Category: Chang BS]]
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==About this Structure==
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[[Category: Fesik SW]]
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1MAZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MAZ OCA].
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[[Category: Harlan JE]]
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[[Category: Liang H]]
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==Reference==
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[[Category: Meadows RP]]
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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death., Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW, Nature. 1996 May 23;381(6580):335-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8692274 8692274]
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[[Category: Muchmore SW]]
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[[Category: Escherichia coli]]
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[[Category: Nettesheim D]]
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[[Category: Single protein]]
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[[Category: Ng SC]]
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[[Category: Chang, B S.]]
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[[Category: Sattler M]]
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[[Category: Fesik, S W.]]
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[[Category: Thompson CB]]
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[[Category: Harlan, J E.]]
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[[Category: Wong SL]]
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[[Category: Liang, H.]]
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[[Category: Yoon HS]]
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[[Category: Meadows, R P.]]
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[[Category: Muchmore, S W.]]
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[[Category: Nettesheim, D.]]
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[[Category: Ng, S C.]]
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[[Category: Sattler, M.]]
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[[Category: Thompson, C B.]]
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[[Category: Wong, S L.]]
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[[Category: Yoon, H S.]]
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[[Category: Apoptosis]]
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[[Category: Bcl-2 family]]
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[[Category: Programmed cell death]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:35:35 2008''
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Current revision

X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH

PDB ID 1maz

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