1mb2

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{{Seed}}
 
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[[Image:1mb2.png|left|200px]]
 
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==Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Tryptophan in an Open Conformation==
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The line below this paragraph, containing "STRUCTURE_1mb2", creates the "Structure Box" on the page.
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<StructureSection load='1mb2' size='340' side='right'caption='[[1mb2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mb2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MB2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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{{STRUCTURE_1mb2| PDB=1mb2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mb2 OCA], [https://pdbe.org/1mb2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mb2 RCSB], [https://www.ebi.ac.uk/pdbsum/1mb2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mb2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYW_GEOSE SYW_GEOSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mb/1mb2_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mb2 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Tryptophan in an Open Conformation===
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12473451}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12473451 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12473451}}
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==About this Structure==
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1MB2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MB2 OCA].
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==Reference==
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Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations., Retailleau P, Huang X, Yin Y, Hu M, Weinreb V, Vachette P, Vonrhein C, Bricogne G, Roversi P, Ilyin V, Carter CW Jr, J Mol Biol. 2003 Jan 3;325(1):39-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12473451 12473451]
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[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Tryptophan--tRNA ligase]]
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[[Category: Bricogne G]]
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[[Category: Bricogne, G.]]
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[[Category: Carter Jr CW]]
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[[Category: Hu, M.]]
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[[Category: Hu M]]
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[[Category: Huang, X.]]
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[[Category: Huang X]]
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[[Category: Ilyin, V.]]
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[[Category: Ilyin V]]
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[[Category: Jr., C W.Carter.]]
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[[Category: Retailleau P]]
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[[Category: Retailleau, P.]]
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[[Category: Roversi P]]
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[[Category: Roversi, P.]]
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[[Category: Vachette P]]
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[[Category: Vachette, P.]]
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[[Category: Vonrhein C]]
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[[Category: Vonrhein, C.]]
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[[Category: Weinreb V]]
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[[Category: Weinreb, V.]]
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[[Category: Yin Y]]
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[[Category: Yin, Y.]]
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[[Category: Amino acid binding site]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:36:00 2008''
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Current revision

Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Tryptophan in an Open Conformation

PDB ID 1mb2

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