1md7

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{{Seed}}
 
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[[Image:1md7.png|left|200px]]
 
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==Monomeric structure of the zymogen of complement protease C1r==
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The line below this paragraph, containing "STRUCTURE_1md7", creates the "Structure Box" on the page.
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<StructureSection load='1md7' size='340' side='right'caption='[[1md7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1md7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MD7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1md7| PDB=1md7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1md7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1md7 OCA], [https://pdbe.org/1md7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1md7 RCSB], [https://www.ebi.ac.uk/pdbsum/1md7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1md7 ProSAT]</span></td></tr>
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</table>
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===Monomeric structure of the zymogen of complement protease C1r===
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== Function ==
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[https://www.uniprot.org/uniprot/C1R_HUMAN C1R_HUMAN] C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12429092}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12429092 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/1md7_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12429092}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1MD7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MD7 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1md7 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism., Budayova-Spano M, Grabarse W, Thielens NM, Hillen H, Lacroix M, Schmidt M, Fontecilla-Camps JC, Arlaud GJ, Gaboriaud C, Structure. 2002 Nov;10(11):1509-19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12429092 12429092]
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</StructureSection>
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[[Category: Complement subcomponent C1r]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arlaud, G J.]]
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[[Category: Arlaud GJ]]
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[[Category: Budayova-Spano, M.]]
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[[Category: Budayova-Spano M]]
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[[Category: Fontecilla-Camps, J.]]
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[[Category: Fontecilla-Camps J]]
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[[Category: Gaboriaud, C.]]
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[[Category: Gaboriaud C]]
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[[Category: Grabarse, W.]]
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[[Category: Grabarse W]]
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[[Category: Hillen, H.]]
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[[Category: Hillen H]]
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[[Category: Lacroix, M.]]
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[[Category: Lacroix M]]
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[[Category: Schmidt, M.]]
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[[Category: Schmidt M]]
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[[Category: Thielens, N M.]]
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[[Category: Thielens NM]]
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[[Category: Activation]]
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[[Category: Complement]]
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[[Category: Innate immunity]]
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[[Category: Serine protease]]
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[[Category: Substrate specificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:43:05 2008''
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Current revision

Monomeric structure of the zymogen of complement protease C1r

PDB ID 1md7

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