1mf6

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{{Seed}}
 
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[[Image:1mf6.png|left|200px]]
 
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==Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy==
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The line below this paragraph, containing "STRUCTURE_1mf6", creates the "Structure Box" on the page.
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<StructureSection load='1mf6' size='340' side='right'caption='[[1mf6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MF6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mf6 OCA], [https://pdbe.org/1mf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mf6 RCSB], [https://www.ebi.ac.uk/pdbsum/1mf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mf6 ProSAT]</span></td></tr>
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{{STRUCTURE_1mf6| PDB=1mf6 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GBG1_BOVIN GBG1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rhodopsin, a prototypical G protein-coupled receptor, catalyzes the activation of a heterotrimeric G protein, transducin, to initiate a visual signaling cascade in photoreceptor cells. The betagamma subunit complex, especially the C-terminal domain of the transducin gamma subunit, Gtgamma(60-71)farnesyl, plays a pivotal role in allosteric regulation of nucleotide exchange on the transducin alpha subunit by light-activated rhodopsin. We report that this domain is unstructured in the presence of an inactive receptor but forms an amphipathic helix upon rhodopsin activation. A K65E/E66K charge reversal mutant of the gamma subunit has diminished interactions with the receptor and fails to adopt the helical conformation. The identification of this conformational switch provides a mechanism for active GPCR utilization of the betagamma complex in signal transfer to G proteins.
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===Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy===
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Rhodopsin controls a conformational switch on the transducin gamma subunit.,Kisselev OG, Downs MA Structure. 2003 Apr;11(4):367-73. PMID:12679015<ref>PMID:12679015</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12679015}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1mf6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12679015 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12679015}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1MF6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MF6 OCA].
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==Reference==
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Rhodopsin controls a conformational switch on the transducin gamma subunit., Kisselev OG, Downs MA, Structure. 2003 Apr;11(4):367-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12679015 12679015]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kisselev, O G.]]
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[[Category: Kisselev OG]]
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[[Category: Bound conformation]]
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[[Category: C-terminal domain]]
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[[Category: G-protein]]
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[[Category: Gamma subunit]]
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[[Category: Gpcr]]
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[[Category: Rhodopsin]]
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[[Category: Transducin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:50:13 2008''
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Current revision

Transducin gamma subunit, C-terminal domain 60-71, rhodopsin-bound state: Ensemble of 15 models determined by TrNOE spectroscopy

PDB ID 1mf6

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