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1mmq

From Proteopedia

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{{Seed}}
 
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[[Image:1mmq.png|left|200px]]
 
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<!--
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==MATRILYSIN COMPLEXED WITH HYDROXAMATE INHIBITOR==
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The line below this paragraph, containing "STRUCTURE_1mmq", creates the "Structure Box" on the page.
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<StructureSection load='1mmq' size='340' side='right'caption='[[1mmq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mmq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MMQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=RRS:N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE'>RRS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1mmq| PDB=1mmq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mmq OCA], [https://pdbe.org/1mmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mmq RCSB], [https://www.ebi.ac.uk/pdbsum/1mmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mmq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mm/1mmq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mmq ConSurf].
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<div style="clear:both"></div>
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===MATRILYSIN COMPLEXED WITH HYDROXAMATE INHIBITOR===
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_7756291}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 7756291 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_7756291}}
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==About this Structure==
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1MMQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMQ OCA].
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==Reference==
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Matrilysin-inhibitor complexes: common themes among metalloproteases., Browner MF, Smith WW, Castelhano AL, Biochemistry. 1995 May 23;34(20):6602-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7756291 7756291]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Matrilysin]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Browner MF]]
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[[Category: Browner, M F.]]
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[[Category: Castelhano AL]]
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[[Category: Castelhano, A L.]]
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[[Category: Smith WW]]
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[[Category: Smith, W W.]]
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[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:23:56 2008''
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Current revision

MATRILYSIN COMPLEXED WITH HYDROXAMATE INHIBITOR

PDB ID 1mmq

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