1io8

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(New page: 200px<br /><applet load="1io8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1io8, resolution 2.0&Aring;" /> '''THERMOPHILIC CYTOCHRO...)
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[[Image:1io8.jpg|left|200px]]<br /><applet load="1io8" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1io8, resolution 2.0&Aring;" />
 
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'''THERMOPHILIC CYTOCHROME P450 (CYP119) FROM SULFOLOBUS SOLFATARICUS: HIGH RESOLUTION STRUCTURAL ORIGIN OF ITS THERMOSTABILITY AND FUNCTIONAL PROPERTIES'''<br />
 
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==About this Structure==
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==Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: High resolution structural origin of its thermostability and functional properties==
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1IO8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus] with HEM as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IO8 OCA].
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<StructureSection load='1io8' size='340' side='right'caption='[[1io8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: Single protein]]
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== Structural highlights ==
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[[Category: Sulfolobus solfataricus]]
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<table><tr><td colspan='2'>[[1io8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IO8 FirstGlance]. <br>
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[[Category: Adachi, S.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Park, S.Y.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1io8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1io8 OCA], [https://pdbe.org/1io8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1io8 RCSB], [https://www.ebi.ac.uk/pdbsum/1io8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1io8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1io8 TOPSAN]</span></td></tr>
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[[Category: Shiro, Y.]]
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</table>
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[[Category: Sligar, S.G.]]
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== Function ==
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[[Category: Yamane, K.]]
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[https://www.uniprot.org/uniprot/CP119_SULAC CP119_SULAC] The endogenous substrate is not known. In vitro, catalyzes the H(2)O(2)-dependent epoxidation of styrene, cis-beta-methylstyrene, and cis-stilbene with retention of stereochemistry. Is able to use cumene hydroperoxide (CHP) or tert-butyl hydroperoxide (TBHP) instead of H(2)O(2) as the electron acceptor. Can also hydroxylate fatty acids such as lauric acid.<ref>PMID:10799487</ref> <ref>PMID:12010041</ref> <ref>PMID:18157853</ref>
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[[Category: HEM]]
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== Evolutionary Conservation ==
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[[Category: crystal structure]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: cytochromo p450]]
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Check<jmol>
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[[Category: riken structural genomics/proteomics initiative]]
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<jmolCheckbox>
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[[Category: rsgi]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/io/1io8_consurf.spt"</scriptWhenChecked>
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[[Category: structural genomics]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: thermophilic]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1io8 ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:32:30 2007''
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Adachi S]]
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[[Category: Park S-Y]]
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[[Category: Shiro Y]]
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[[Category: Sligar SG]]
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[[Category: Yamane K]]

Current revision

Thermophilic cytochrome P450 (CYP119) from sulfolobus solfataricus: High resolution structural origin of its thermostability and functional properties

PDB ID 1io8

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