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1is4

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LACTOSE-LIGANDED CONGERIN II

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1is4"

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-[[Image:1is4.jpg|left|200px]]<br /><applet load="1is4" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1is4, resolution 1.90&Aring;" />
-'''LACTOSE-LIGANDED CONGERIN II'''<br />
-==Overview==
+==LACTOSE-LIGANDED CONGERIN II==
-The crystal structure of congerin II, a galectin family lectin from conger, eel, was determined at 1.45A resolution. The previously determined, structure of its isoform, congerin I, had revealed a fold evolution via, strand swap; however, the structure of congerin II described here, resembles other prototype galectins. A comparison of the two congerin, genes with that of several other galectins suggests acceralated evolution, of both congerin genes following gene duplication. The presence of a Mes, (2-[N-morpholino]ethanesulfonic acid) molecule near the, carbohydrate-binding site in the crystal structure points to the, possibility of an additional binding site in congerin II. The binding site, consists of a group of residues that had been replaced following gene, duplication suggesting that the binding site was built under selective, pressure. Congerin II may be a protein specialized for biological defense, with an affinity for target carbohydrates on parasites' cell surface.
+<StructureSection load='1is4' size='340' side='right'caption='[[1is4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1is4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IS4 FirstGlance]. <br>
-IS4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Conger_myriaster Conger myriaster] with LAT as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IS4 OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1is4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1is4 OCA], [https://pdbe.org/1is4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1is4 RCSB], [https://www.ebi.ac.uk/pdbsum/1is4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1is4 ProSAT]</span></td></tr>
-Crystal structure of a conger eel galectin (congerin II) at 1.45A resolution: implication for the accelerated evolution of a new ligand-binding site following gene duplication., Shirai T, Matsui Y, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K, J Mol Biol. 2002 Aug 30;321(5):879-89. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12206768 12206768]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LEG2_CONMY LEG2_CONMY] This protein binds beta-galactoside. Its physiological function is not yet known.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/is/1is4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1is4 ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Conger myriaster]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Ishii, C.]]
+[[Category: Ishii C]]
-[[Category: Kamiya, H.]]
+[[Category: Kamiya H]]
-[[Category: Matsui, Y.]]
+[[Category: Matsui Y]]
-[[Category: Muramoto, K.]]
+[[Category: Muramoto K]]
-[[Category: Ogawa, T.]]
+[[Category: Ogawa T]]
-[[Category: Shionyu-Mitsuyama, C.]]
+[[Category: Shionyu-Mitsuyama C]]
-[[Category: Shirai, T.]]
+[[Category: Shirai T]]
-[[Category: Yamane, T.]]
+[[Category: Yamane T]]
-[[Category: LAT]]
-[[Category: beta sandwich]]
-[[Category: complex with lactose]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:37:33 2007''

1is4

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LACTOSE-LIGANDED CONGERIN II

Structural highlights

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Evolutionary Conservation

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