3sgb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:18, 1 January 2020) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3sgb.png|left|200px]]
 
-
<!--
+
==STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION==
-
The line below this paragraph, containing "STRUCTURE_3sgb", creates the "Structure Box" on the page.
+
<StructureSection load='3sgb' size='340' side='right'caption='[[3sgb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3sgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_griseus"_krainsky_1914 "actinomyces griseus" krainsky 1914]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2sgb 2sgb] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1sgb 1sgb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGB FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgb OCA], [http://pdbe.org/3sgb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sgb RCSB], [http://www.ebi.ac.uk/pdbsum/3sgb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgb ProSAT]</span></td></tr>
-
-->
+
</table>
-
{{STRUCTURE_3sgb| PDB=3sgb | SCENE= }}
+
== Function ==
 +
[[http://www.uniprot.org/uniprot/PRTB_STRGR PRTB_STRGR]] Has a primary specificity for large aliphatic or aromatic amino acids.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sg/3sgb_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3sgb ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structure of the complex between the serine protease Streptomyces griseus protease B (SGPB) and the third domain of the Kazal-type ovomucoid inhibitor from turkey has been solved at 1.8-A resolution and refined to a conventional R factor of 0.125. As others have reported previously for analogous complexes of proteases and protein inhibitors, the inhibitor binds in a fashion similar to that of a substrate; it is not cleaved, but there is a close approach (2.7 A) of the active site nucleophile Ser-195 O gamma to the carbonyl carbon of the reactive peptide bond of the inhibitor. Contrary to the structural reports regarding the other enzyme-inhibitor complexes, we conclude that there is no evidence for a significant distortion of this peptide bond from planarity. The mechanism of inhibition can be understood in terms of the equilibrium thermodynamic parameters Ka, the enzyme-inhibitor association constant, and Khyd, the equilibrium constant for inhibitor hydrolysis. These thermodynamic parameters can be rationalized in terms of the observed structure.
-
===STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION===
+
Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution.,Read RJ, Fujinaga M, Sielecki AR, James MN Biochemistry. 1983 Sep 13;22(19):4420-33. PMID:6414511<ref>PMID:6414511</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3sgb" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_6414511}}, adds the Publication Abstract to the page
+
*[[Proteinase|Proteinase]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 6414511 is the PubMed ID number.
+
*[[Proteinase 3D structures|Proteinase 3D structures]]
-
-->
+
== References ==
-
{{ABSTRACT_PUBMED_6414511}}
+
<references/>
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
3SGB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Streptomyces_griseus Streptomyces griseus]. This structure supersedes the now removed PDB entries and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1sgb 1sgb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGB OCA].
+
[[Category: Actinomyces griseus krainsky 1914]]
-
 
+
[[Category: Large Structures]]
-
==Reference==
+
[[Category: Fujinaga, M]]
-
Structure of the complex of Streptomyces griseus protease B and the third domain of the turkey ovomucoid inhibitor at 1.8-A resolution., Read RJ, Fujinaga M, Sielecki AR, James MN, Biochemistry. 1983 Sep 13;22(19):4420-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/6414511 6414511]
+
[[Category: James, M N.G]]
-
[[Category: Protein complex]]
+
[[Category: Read, R J]]
-
[[Category: Streptomyces griseus]]
+
[[Category: Sielecki, A R]]
-
[[Category: Fujinaga, M.]]
+
-
[[Category: James, M N.G.]]
+
-
[[Category: Read, R J.]]
+
-
[[Category: Sielecki, A R.]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:07:03 2008''
+

Current revision

STRUCTURE OF THE COMPLEX OF STREPTOMYCES GRISEUS PROTEASE B AND THE THIRD DOMAIN OF THE TURKEY OVOMUCOID INHIBITOR AT 1.8 ANGSTROMS RESOLUTION

PDB ID 3sgb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3sgb"
Personal tools