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471d

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{{Seed}}
 
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[[Image:471d.png|left|200px]]
 
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==CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA==
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The line below this paragraph, containing "STRUCTURE_471d", creates the "Structure Box" on the page.
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<StructureSection load='471d' size='340' side='right' caption='[[471d]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[471d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=471D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=471D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A44:2-O-METHYOXYETHYL-ADENOSINE+5-MONOPHOSPHATE'>A44</scene>, <scene name='pdbligand=C43:2-O-METHYOXYETHYL-CYTIDINE-5-MONOPHOSPHATE'>C43</scene>, <scene name='pdbligand=G48:2-O-METHYOXYETHYL-GUANOSINE-5-MONOPHOSPHATE'>G48</scene>, <scene name='pdbligand=U36:2-O-METHYOXYETHYL-URIDINE-5-MONOPHOSPHATE'>U36</scene></td></tr>
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{{STRUCTURE_471d| PDB=471d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=471d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=471d OCA], [http://pdbe.org/471d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=471d RCSB], [http://www.ebi.ac.uk/pdbsum/471d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=471d ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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2'-O-(2-Methoxyethyl)-RNA (MOE-RNA) is a nucleic acid analog with promising features for antisense applications. Compared with phosphorothioate DNA (PS-DNA), the MOE modification offers improved nuclease resistance, enhanced RNA affinity, improved cellular uptake and intestinal absorption, reduced toxicity and immune stimulation. The crystal structure of a fully modified MOE-RNA dodecamer duplex (CGCGAAUUCGCG) was determined at 1.7 A resolution. In the majority of the MOE substituents, the torsion angle around the ethylene alkyl chain assumes a gauche conformation. The conformational preorganization of the MOE groups is consistent with the improved RNA affinity and the extensive hydration of the substituents could play a role in the improved cellular uptake of MOE-RNA. A specific hydration pattern that bridges substituent and phosphate oxygen atoms in the minor groove of MOE-RNA may explain its high nuclease resistance.
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===CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA===
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Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.,Teplova M, Minasov G, Tereshko V, Inamati GB, Cook PD, Manoharan M, Egli M Nat Struct Biol. 1999 Jun;6(6):535-9. PMID:10360355<ref>PMID:10360355</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 471d" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10360355 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10360355}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Cook, P D]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=471D OCA].
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[[Category: Egli, M]]
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[[Category: Inamati, G]]
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==Reference==
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[[Category: Minasov, G]]
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Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA., Teplova M, Minasov G, Tereshko V, Inamati GB, Cook PD, Manoharan M, Egli M, Nat Struct Biol. 1999 Jun;6(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10360355 10360355]
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[[Category: Teplova, M]]
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[[Category: Cook, P D.]]
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[[Category: Tereshko, V]]
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[[Category: Egli, M.]]
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[[Category: Inamati, G.]]
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[[Category: Minasov, G.]]
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[[Category: Teplova, M.]]
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[[Category: Tereshko, V.]]
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
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[[Category: Rna]]
[[Category: Rna dodecamer duplex]]
[[Category: Rna dodecamer duplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:24:27 2008''
 

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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA

471d, resolution 2.70Å

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