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488d

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{{Seed}}
 
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[[Image:488d.png|left|200px]]
 
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==CATALYTIC RNA ENZYME-PRODUCT COMPLEX==
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The line below this paragraph, containing "STRUCTURE_488d", creates the "Structure Box" on the page.
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<StructureSection load='488d' size='340' side='right'caption='[[488d]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[488d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=488D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=488D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCC:CYTIDINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>CCC</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr>
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{{STRUCTURE_488d| PDB=488d | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=488d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=488d OCA], [https://pdbe.org/488d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=488d RCSB], [https://www.ebi.ac.uk/pdbsum/488d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=488d ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We have determined the crystal structure of the enzyme-product complex of the hammerhead ribozyme by using a reinforced crystal lattice to trap the complex prior to dissociation and by employing X-ray holographic image reconstruction, a real-space electron density imaging and refinement procedure. Subsequent to catalysis, the cleavage site residue (C-17), together with its 2',3'-cyclic phosphate, adopts a conformation close to and approximately perpendicular to the Watson-Crick base-pairing faces of two highly conserved purines in the ribozyme's catalytic pocket (G-5 and A-6). We observe several interactions with functional groups on these residues that have been identified as critical for ribozyme activity by biochemical analyses but whose role has defied explanation in terms of previous structural analyses. These interactions may therefore be relevant to the hammerhead ribozyme reaction mechanism.
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===CATALYTIC RNA ENZYME-PRODUCT COMPLEX===
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Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction.,Murray JB, Szoke H, Szoke A, Scott WG Mol Cell. 2000 Feb;5(2):279-87. PMID:10882069<ref>PMID:10882069</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 488d" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10882069}}, adds the Publication Abstract to the page
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*[[Ribozyme 3D structures|Ribozyme 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10882069 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10882069}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=488D OCA].
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[[Category: Murray JB]]
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[[Category: Scott WG]]
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==Reference==
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[[Category: Szoke A]]
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Capture and visualization of a catalytic RNA enzyme-product complex using crystal lattice trapping and X-ray holographic reconstruction., Murray JB, Szoke H, Szoke A, Scott WG, Mol Cell. 2000 Feb;5(2):279-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10882069 10882069]
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[[Category: Szoke H]]
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[[Category: Murray, J B.]]
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[[Category: Scott, W G.]]
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[[Category: Szoke, A.]]
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[[Category: Szoke, H.]]
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[[Category: Catalytic rna]]
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[[Category: Crystal lattice trapping]]
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[[Category: Enzyme-product complex]]
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[[Category: Ribozyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:26:51 2008''
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Current revision

CATALYTIC RNA ENZYME-PRODUCT COMPLEX

PDB ID 488d

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