3dez

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(New page: '''Unreleased structure''' The entry 3dez is ON HOLD until Paper Publication Authors: Liu, C.P., Gao, Z.Q., Xu, J.H., Hou, H.F., Li, L.F., Su, X.D., Liu, P., Xian, D.C., Dong, Y.H. Des...)
Current revision (15:08, 1 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3dez is ON HOLD until Paper Publication
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==Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans==
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<StructureSection load='3dez' size='340' side='right'caption='[[3dez]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3dez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DEZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dez OCA], [https://pdbe.org/3dez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dez RCSB], [https://www.ebi.ac.uk/pdbsum/3dez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dez ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRE_STRMU PYRE_STRMU] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/de/3dez_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dez ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Orotate phosphoribosyltransferase (OPRTase) catalyzes the OMP-forming step in de novo pyrimidine-nucleotide biosynthesis. Here, the crystal structure of OPRTase from the caries pathogen Streptococcus mutans is reported at 2.4 A resolution. S. mutans OPRTase forms a symmetric dimer and each monomer binds two sulfates at the active sites. The structural symmetry of the sulfate-binding sites and the missing loops in this structure are consistent with a symmetric catalysis mechanism.
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Authors: Liu, C.P., Gao, Z.Q., Xu, J.H., Hou, H.F., Li, L.F., Su, X.D., Liu, P., Xian, D.C., Dong, Y.H.
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Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans.,Liu CP, Xu R, Gao ZQ, Xu JH, Hou HF, Li LQ, She Z, Li LF, Su XD, Liu P, Dong YH Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 May 1;66(Pt, 5):498-502. Epub 2010 Apr 29. PMID:20445243<ref>PMID:20445243</ref>
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Description: Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3dez" style="background-color:#fffaf0;"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Jul 11 13:06:56 2008''
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Streptococcus mutans]]
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[[Category: Dong YH]]
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[[Category: Gao ZQ]]
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[[Category: Hou HF]]
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[[Category: Li LF]]
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[[Category: Liu CP]]
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[[Category: Su XD]]

Current revision

Crystal structure of Orotate phosphoribosyltransferase from Streptococcus mutans

PDB ID 3dez

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