This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3dkn
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3dkn is ON HOLD Authors: Jean-Francois Menetret, Christopher Akey, Northeast Structural Genomics Consortium (NESG) Description: Sec61 in the Canine...) |
|||
| (13 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum== | |
| + | <SX load='3dkn' size='340' side='right' viewer='molstar' caption='[[3dkn]], [[Resolution|resolution]] 8.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3dkn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DKN FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.7Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dkn OCA], [https://pdbe.org/3dkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dkn RCSB], [https://www.ebi.ac.uk/pdbsum/3dkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dkn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SECY_METJA SECY_METJA] The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/3dkn_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dkn ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| - | + | *[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </SX> | |
| - | + | [[Category: Canis lupus familiaris]] | |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Akey C]] | ||
| + | [[Category: Menetret J-F]] | ||
Current revision
Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum
| |||||||||
