3dlx
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3dlx is ON HOLD Authors: Oppermann, U., Kavanagh, K.L., Structural Genomics Consortium (SGC) Description: Crystal structure of human 3-oxoacid CoA ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human 3-oxoacid CoA transferase 1== | |
| - | + | <StructureSection load='3dlx' size='340' side='right'caption='[[3dlx]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3dlx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DLX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dlx OCA], [https://pdbe.org/3dlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dlx RCSB], [https://www.ebi.ac.uk/pdbsum/3dlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dlx ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SCOT1_HUMAN SCOT1_HUMAN] Succinyl-CoA:3-ketoacid CoA transferase deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SCOT1_HUMAN SCOT1_HUMAN] Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dl/3dlx_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dlx ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Kavanagh KL]] | ||
| + | [[Category: Maclean EM]] | ||
| + | [[Category: Murray JW]] | ||
| + | [[Category: Oppermann U]] | ||
| + | [[Category: Picaud S]] | ||
| + | [[Category: Roos AK]] | ||
| + | [[Category: Shafqat N]] | ||
| + | [[Category: Wikstrom M]] | ||
| + | [[Category: Yue WW]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of human 3-oxoacid CoA transferase 1
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards AM | Kavanagh KL | Maclean EM | Murray JW | Oppermann U | Picaud S | Roos AK | Shafqat N | Wikstrom M | Yue WW | Von Delft F
