2z5t

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{{Seed}}
 
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[[Image:2z5t.png|left|200px]]
 
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==Molecular basis for the inhibition of p53 by Mdmx==
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The line below this paragraph, containing "STRUCTURE_2z5t", creates the "Structure Box" on the page.
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<StructureSection load='2z5t' size='340' side='right'caption='[[2z5t]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2z5t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5t OCA], [https://pdbe.org/2z5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5t RCSB], [https://www.ebi.ac.uk/pdbsum/2z5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5t ProSAT]</span></td></tr>
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{{STRUCTURE_2z5t| PDB=2z5t | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDM4_DANRE MDM4_DANRE] Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The oncoprotein Mdm2, and the recently intensely studied, homologues protein Mdmx, are principal negative regulators of the p53 tumor suppressor. The mechanisms by which they regulate the stability and activity of p53 are not fully established. We have determined the crystal structure of the N-terminal domain of Mdmx bound to a 15-residue p53 peptide. The structure reveals that although the principle features of the Mdm2-p53 interaction are preserved in the Mdmx-p53 complex, the Mdmx hydrophobic cleft on which the p53 peptide binds is significantly altered: a part of the cleft is blocked by sidechains of Met and Tyr of the p53-binding pocket of Mdmx. Thus specific inhibitors of Mdm2-p53 would not be optimal for binding to Mdmx. Our binding assays show indeed that nutlins, the newly discovered, potent antagonists of the Mdm2-p53 interaction, are not capable to efficiently disrupt the Mdmx-p53 interaction. To achieve full activation of p53 in tumor cells, compounds that are specific for Mdmx are necessary to complement the Mdm2 specific binders.
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===Molecular basis for the inhibition of p53 by Mdmx===
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Molecular Basis for the Inhibition of p53 by Mdmx.,Popowicz GM, Czarna A, Rothweiler U, Sszwagierczak A, Krajewski M, Weber L, Holak TA Cell Cycle. 2007 Jul 12;6(19). PMID:17938582<ref>PMID:17938582</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2z5t" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17938582}}, adds the Publication Abstract to the page
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*[[MDM4|MDM4]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17938582 is the PubMed ID number.
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*[[P53 3D structures|P53 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_17938582}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2Z5T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5T OCA].
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==Reference==
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Molecular Basis for the Inhibition of p53 by Mdmx., Popowicz GM, Czarna A, Rothweiler U, Sszwagierczak A, Krajewski M, Weber L, Holak TA, Cell Cycle. 2007 Jul 12;6(19). PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17938582 17938582]
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[[Category: Danio rerio]]
[[Category: Danio rerio]]
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[[Category: Protein complex]]
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[[Category: Homo sapiens]]
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[[Category: Czarna, A.]]
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[[Category: Large Structures]]
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[[Category: Holak, T A.]]
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[[Category: Czarna A]]
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[[Category: Popowicz, G M.]]
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[[Category: Holak TA]]
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[[Category: Rothweiler, U.]]
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[[Category: Popowicz GM]]
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[[Category: Szwagierczak, A.]]
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[[Category: Rothweiler U]]
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[[Category: Acetylation]]
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[[Category: Szwagierczak A]]
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[[Category: Activator]]
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[[Category: Anti-oncogene]]
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[[Category: Apoptosis]]
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[[Category: Cell cycle]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Mdm2]]
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[[Category: Mdm4]]
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[[Category: Mdmx]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 08:48:05 2008''
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Current revision

Molecular basis for the inhibition of p53 by Mdmx

PDB ID 2z5t

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