3dcy

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{{Seed}}
 
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[[Image:3dcy.jpg|left|200px]]
 
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==Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.==
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The line below this paragraph, containing "STRUCTURE_3dcy", creates the "Structure Box" on the page.
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<StructureSection load='3dcy' size='340' side='right'caption='[[3dcy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3dcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DCY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.748&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_3dcy| PDB=3dcy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dcy OCA], [https://pdbe.org/3dcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dcy RCSB], [https://www.ebi.ac.uk/pdbsum/3dcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dcy ProSAT], [https://www.topsan.org/Proteins/CESG/3dcy TOPSAN]</span></td></tr>
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</table>
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===Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.===
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== Function ==
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[https://www.uniprot.org/uniprot/TIGAR_HUMAN TIGAR_HUMAN] Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.<ref>PMID:16839880</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3DCY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCY OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/3dcy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dcy ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bingman, C A.]]
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[[Category: Bingman CA]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: McCoy JG]]
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[[Category: Jr., G N.Phillips.]]
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[[Category: Phillips Jr GN]]
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[[Category: McCoy, J G.]]
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[[Category: Wesenberg GE]]
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[[Category: Wesenberg, G E.]]
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[[Category: C12orf5]]
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[[Category: Casp target]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
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[[Category: Isomerase]]
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[[Category: Omim 610775]]
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[[Category: Phosphoprotein]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomics medical relevance]]
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[[Category: Tigar]]
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[[Category: Tp53-induced glycolysis and apoptosis regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 10:52:12 2008''
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Current revision

Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.

PDB ID 3dcy

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