Chitinase

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(New page: ==This is a placeholder== Chitinases cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria a...)
Current revision (09:45, 8 May 2019) (edit) (undo)
 
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==This is a placeholder==
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<StructureSection load='3wh1' size='350' side='right' caption='Chitinase A complex with (GlcNac)4 and ethylene glycol (PDB entry [[3wh1]])' scene='27/271631/Cv/3'>
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Chitinases cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi.
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__TOC__
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== Function ==
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{{STRUCTURE_1ffq | PDB=1ffq | SCENE= }}
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[[Chitinase]]s (Chi) cleave the beta-1-4-glycosidic bond between the N-acetyl-D-glucosamine units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi. The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed. <ref>PMID:21054166</ref>. <br />
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* '''Chitinase I''' is found in plants.<br />
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* '''Chitinase II''' is found in plants, fungi and bacteria.<br />
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* '''Chitinase III''' has no sequence similarity to class I or II.<br />
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* '''Chitinase IV''' has similar characteristics to class I but are smaller than it.<br />
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The first chitinase structures were solved in 1994, from a bacterium ([[1ctn]]) and a plant ([[2hvm]]). A mechanism for chitin cleavage was proposed based on several structures and was later confirmed.
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==Disease ==
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Chi is related to allergies and asthma<ref>PMID:19295241</ref>.
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== Structural highlights ==
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The <scene name='27/271631/Cv/5'>chitin tetrasaccharide binding site</scene> of Chitinase A. <ref>PMID:24582745</ref> Water molecules are shown as red spheres.
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== 3D Structures of Chitinase ==
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[[Chitinase 3D structures]]
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</StructureSection>
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Chitinase A complex with (GlcNac)4 and ethylene glycol (PDB entry 3wh1)

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References

  1. ↑ Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury. Annu Rev Physiol. 2011;73:479-501. doi: 10.1146/annurev-physiol-012110-142250. PMID:21054166 doi:http://dx.doi.org/10.1146/annurev-physiol-012110-142250
  2. ↑ Shuhui L, Mok YK, Wong WS. Role of mammalian chitinases in asthma. Int Arch Allergy Immunol. 2009;149(4):369-77. doi: 10.1159/000205583. Epub 2009, Mar 17. PMID:19295241 doi:http://dx.doi.org/10.1159/000205583
  3. ↑ Ohnuma T, Umemoto N, Nagata T, Shinya S, Numata T, Taira T, Fukamizo T. Crystal structure of a "loopless" GH19 chitinase in complex with chitin tetrasaccharide spanning the catalytic center. Biochim Biophys Acta. 2014 Feb 25;1844(4):793-802. doi:, 10.1016/j.bbapap.2014.02.013. PMID:24582745 doi:http://dx.doi.org/10.1016/j.bbapap.2014.02.013
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