2r7l

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{{Seed}}
 
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[[Image:2r7l.png|left|200px]]
 
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==Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR==
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The line below this paragraph, containing "STRUCTURE_2r7l", creates the "Structure Box" on the page.
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<StructureSection load='2r7l' size='340' side='right'caption='[[2r7l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R7L FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2r7l| PDB=2r7l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7l OCA], [https://pdbe.org/2r7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r7l RCSB], [https://www.ebi.ac.uk/pdbsum/2r7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r7l ProSAT]</span></td></tr>
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</table>
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===Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR===
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== Function ==
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[https://www.uniprot.org/uniprot/PURP_METJA PURP_METJA] Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.<ref>PMID:15623504</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18069798}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18069798 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/2r7l_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18069798}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2R7L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7L OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r7l ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii., Zhang Y, White RH, Ealick SE, Biochemistry. 2008 Jan 8;47(1):205-17. Epub 2007 Dec 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18069798 18069798]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
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[[Category: Single protein]]
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[[Category: Ealick SE]]
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[[Category: Ealick, S E.]]
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[[Category: White RH]]
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[[Category: White, R H.]]
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[[Category: Zhang Y]]
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[[Category: Zhang, Y.]]
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[[Category: Atp-binding]]
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[[Category: Atp-grasp superfamily]]
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[[Category: Ligase]]
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[[Category: Magnesium]]
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[[Category: Manganese]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:04:01 2008''
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Current revision

Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR

PDB ID 2r7l

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