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3bsu

From Proteopedia

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{{Seed}}
 
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[[Image:3bsu.png|left|200px]]
 
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<!--
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==Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA==
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The line below this paragraph, containing "STRUCTURE_3bsu", creates the "Structure Box" on the page.
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<StructureSection load='3bsu' size='340' side='right'caption='[[3bsu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3bsu]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BSU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5IU:5-IODO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3bsu| PDB=3bsu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bsu OCA], [https://pdbe.org/3bsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bsu RCSB], [https://www.ebi.ac.uk/pdbsum/3bsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bsu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNH1_HUMAN RNH1_HUMAN] Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bs/3bsu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bsu ConSurf].
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<div style="clear:both"></div>
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===Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA===
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==See Also==
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18337749}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18337749 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18337749}}
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==About this Structure==
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3BSU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BSU OCA].
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==Reference==
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Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD., Nowotny M, Cerritelli SM, Ghirlando R, Gaidamakov SA, Crouch RJ, Yang W, EMBO J. 2008 Mar 13;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18337749 18337749]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ribonuclease H]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Cerritelli SM]]
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[[Category: Cerritelli, S M.]]
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[[Category: Crouch RJ]]
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[[Category: Crouch, R J.]]
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[[Category: Gaidamakov SA]]
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[[Category: Gaidamakov, S A.]]
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[[Category: Ghirlando R]]
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[[Category: Ghirlando, R.]]
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[[Category: Nowotny M]]
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[[Category: Nowotny, M.]]
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[[Category: Yang W]]
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[[Category: Yang, W.]]
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[[Category: Dsrna]]
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[[Category: Hydrolase/rna/dna complex]]
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[[Category: Rna/dna hybrid]]
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[[Category: Rnase h]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:09:17 2008''
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Current revision

Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA

PDB ID 3bsu

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