1oyd

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{{Seed}}
 
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[[Image:1oyd.png|left|200px]]
 
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==Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump==
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The line below this paragraph, containing "STRUCTURE_1oyd", creates the "Structure Box" on the page.
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<StructureSection load='1oyd' size='340' side='right'caption='[[1oyd]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1oyd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The November 2007 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Multidrug Resistance Transporters'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2007_11 10.2210/rcsb_pdb/mom_2007_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OYD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DEQ:DEQUALINIUM'>DEQ</scene></td></tr>
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{{STRUCTURE_1oyd| PDB=1oyd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oyd OCA], [https://pdbe.org/1oyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oyd RCSB], [https://www.ebi.ac.uk/pdbsum/1oyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oyd ProSAT]</span></td></tr>
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</table>
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===Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump===
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== Function ==
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[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12738864 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/1oyd_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12738864}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1OYD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Additional information on 1OYD is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb95_1.html Multidrug Resistance Transporters] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OYD OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oyd ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump., Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr, Science. 2003 May 9;300(5621):976-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12738864 12738864]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Large Structures]]
[[Category: Multidrug Resistance Transporters]]
[[Category: Multidrug Resistance Transporters]]
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[[Category: Single protein]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Jr., D E.Koshland.]]
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[[Category: Koshland Jr DE]]
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[[Category: MeDermott, G.]]
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[[Category: MeDermott G]]
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[[Category: Nikaido, H.]]
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[[Category: Nikaido H]]
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[[Category: Yu, E W.]]
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[[Category: Yu EW]]
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[[Category: Zgurskaya, H I.]]
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[[Category: Zgurskaya HI]]
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[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:53:52 2008''
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Current revision

Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump

PDB ID 1oyd

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